ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Development of the Cerebral Cortex across Adolescence: A Multisample Study of Inter-Related Longitudinal Changes in Cortical Volume, Surface Area, and Thickness.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 376 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
376 citing papers in PubMed, 2 syntheses or guidelines pooled it, 719 citations in OpenAlex.
- Exploration of brain imaging biomarkers in subthreshold depression patients across different ages: an ALE meta-analysis based on MRI studies.BMC psychiatry · 2025Pooled it
- Early biological and psychosocial factors associated with PTSD onset and persistence in youth.European journal of psychotraumatology · 2024Pooled it
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Physical Activity and Adolescent Brain Structure, Mental Health, and Academic Outcomes.JAMA network open · 2026Article
- Sleep and participation in extracurricular activities moderate associations between low SES and brain structure and functional connectivity.Developmental cognitive neuroscience · 2026Article
- Puberty, pregnancy, and menopause show shared and distinct structural changes across the lifespan.Nature communications · 2026Article
- Engagement, preference and identity: Proposing a developmental engagement framework.The British journal of developmental psychology · 2026Review
- Neural correlates of resilience to trauma during adolescence: A multi-modal study.JCPP advances · 2026Article
- Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.Biological psychiatry global open science · 2026Review
- Brain structural pathways linking dietary patterns and cognitive performance in adolescents.Brain structure & function · 2026Article
- The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets.Schizophrenia bulletin · 2026Article
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- Experience-dependent cortical plasticity in response to formal schooling: Effects on networks for reading and mathematics.Developmental cognitive neuroscience · 2026Article
- Heritable and experience-dependent cortical traits of reading ability.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cognitive ability in childhood predicts adolescent structural and functional brain development: A longitudinal study.Developmental cognitive neuroscience · 2026Article
- Maturation of Cortical Auditory Evoked Potentials in Response to Tones and Noise During Adolescence and Young Adulthood.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Screen time patterns and cognitive screening outcomes (MoCA-Ina) in adolescents: a cross-sectional study.BMC neurology · 2026Observational
- Identifying associations and key early life exposure windows for organophosphate esters and adolescent brain morphometry in the HOME study.Environmental research · 2026Article
- Timing and tempo of puberty and neurodevelopment following adversity: A registered report.Developmental cognitive neuroscience · 2026Article
- Parenting behaviors over time and their effects on cortical and limbic brain structure in children and young adults.Developmental cognitive neuroscience · 2026Article
316 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 7 countries.
Funding
Abstract
Before we can assess and interpret how developmental changes in human brain structure relate to cognition, affect, and motivation, and how these processes are perturbed in clinical or at-risk populations, we must first precisely understand typical brain development and how changes in different structural components relate to each other. We conducted a multisample magnetic resonance imaging study to investigate the development of cortical volume, surface area, and thickness, as well as their inter-relationships, from late childhood to early adulthood (7-29 years) using four separate longitudinal samples including 388 participants and 854 total scans. These independent datasets were processed and quality-controlled using the same methods, but analyzed separately to study the replicability of the results across sample and image-acquisition characteristics. The results consistently showed widespread and regionally variable nonlinear decreases in cortical volume and thickness and comparably smaller steady decreases in surface area. Further, the dominant contributor to cortical volume reductions during adolescence was thinning. Finally, complex regional and topological patterns of associations between changes in surface area and thickness were observed. Positive relationships were seen in sulcal regions in prefrontal and temporal cortices, while negative relationships were seen mainly in gyral regions in more posterior cortices. Collectively, these results help resolve previous inconsistencies regarding the structural development of the cerebral cortex from childhood to adulthood, and provide novel insight into how changes in the different dimensions of the cortex in this period of life are inter-related.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.