ArticleThe Journal of biological chemistry2017
Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Weight Loss During Obesity Provokes Asparaginase-Associated Liver Steatosis and Endoplasmic Reticulum Stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- High-throughput multi-organ proteomics workflow for drug efficacy and toxicity analysis.Nature communications · 2026Article
- Clinical evidence and biological mechanisms linking obesity to adverse outcomes in pediatric and adolescent acute lymphoblastic leukemia.Frontiers in oncology · 2026Review
- Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Autophagy-related 7 (ATG7) regulates food intake and liver health during asparaginase exposure.The Journal of biological chemistry · 2025Article
- Effects of asparaginases and L-carnitine on Western-diet-induced hepatosteatosis in mice.F1000Research · 2022Article
- Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice.Acta pharmaceutica Sinica. B · 2021Article
- Levocarnitine for pegaspargase-induced hepatotoxicity in older children and young adults with acute lymphoblastic leukemia.Cancer medicine · 2021Article
- Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress.Nucleic acids research · 2021Article
- Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex.The Journal of nutrition · 2021Article
- Amino acid sensing pathway: A major check point in the pathogenesis of obesity and COVID-19.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Review
- Review
- Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling.Cellular and molecular gastroenterology and hepatology · 2020Article
- Age modulates liver responses to asparaginase-induced amino acid stress in mice.The Journal of biological chemistry · 2019Article
- Multiple Severe Toxicities of L-Asparaginase and Their Innovative Management during Induction Therapy of Acute Lymphoblastic Leukemia in an Adult Patient.Case reports in hematology · 2019Article
- Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature.Leukemia & lymphoma · 2018Review
- The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.European journal of applied physiology · 2018Article
- Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.The Journal of biological chemistry · 2018Article
- Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells.Cell death & disease · 2018Article
- Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.Physiological reports · 2017Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Inna A NikonorovaFrom the Department of Nutritional Sciences, and.
Rana J T Al-Baghdadithe Endocrinology and Animal Biosciences Graduate Program, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901.
Emily T MirekFrom the Department of Nutritional Sciences, and.
Yongping WangFrom the Department of Nutritional Sciences, and.
Michael P GoudieFrom the Department of Nutritional Sciences, and.
Berish B WetsteinFrom the Department of Nutritional Sciences, and.
Joseph L DixonFrom the Department of Nutritional Sciences, and.
Christopher Hinethe Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115.
James R Mitchellthe Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115.
Christopher M Adamsthe Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, and.
Ronald C Wekthe Department of Biochemistry and Molecular Biology, Indiana University, School of Medicine, Indianapolis, Indiana 46202.ORCID 0000-0002-2087-5504
Tracy G AnthonyFrom the Department of Nutritional Sciences, and tracy.anthony@rutgers.edu.ORCID 0000-0002-8586-5884
Rutgers, The State University of New Jersey · USHarvard University · USIndiana University – Purdue University Indianapolis · USUniversity of Iowa · US
Funding
Homeostatic Responses to Amino Acid InsufficiencyR01DK109714 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI ANTHONY, TRACY G., WEK, RONALD C · 2016 to 2024
$5.4MMolecular Mechanisms of Adverse Metabolic Events by Asparaginase.R01HD070487 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI ANTHONY, TRACY G. · 2011 to 2015
$1.9MMolecular Pathogenesis of Skeletal Muscle AtrophyR01AR059115 · NIAMS · UNIVERSITY OF IOWA · PI ADAMS, CHRISTOPHER M · 2010 to 2014
$1.6MRequirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747kRequirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionK99AG050777 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI HINE, CHRISTOPHER MICHAEL · 2015 to 2016
$257kMolecular Mechanisms of Age-related Muscle LossI01BX000976 · VA · IOWA CITY VA MEDICAL CENTER · PI YOREK, MARK A. · 2012 to 2022
–Prevention and Treatment of Skeletal Muscle AtrophyI01RX001477 · VA · IOWA CITY VA MEDICAL CENTER · PI ADAMS, CHRISTOPHER M · 2015 to 2017
–BLRD VA I01 BX000976NIAMS NIH HHS R01 AR059115NIA NIH HHS K99 AG050777NIA NIH HHS R00 AG050777NICHD NIH HHS R01 HD070487NIDDK NIH HHS R01 DK109714RRD VA I01 RX001477
Abstract
Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress response (ISR) via sensing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2. The goal of this work was to discern the impact of obesity, alone
Indexed as
Activating Transcription Factor 4Activating Transcription FactorsAnimalsApolipoprotein B-100AsparaginaseCell Cycle ProteinsDisease Models, AnimaleIF-2 KinaseEukaryotic Initiation Factor-2Fatty LiverGene DeletionGlutathioneHydrogen SulfideLiverMechanistic Target of Rapamycin Complex 1MiceActivating Transcription Factor 4Activating Transcription FactorsApolipoprotein B-100AsparaginaseAtf4 protein, mouseAtf5 protein, mouseCell Cycle ProteinsEif2ak4 protein, mouseeIF-2 KinaseEukaryotic Initiation Factor-2GlutathioneHydrogen SulfideMechanistic Target of Rapamycin Complex 1Multiprotein ComplexesNuclear ProteinsPeroxidasesProtein Serine-Threonine KinasesSesn2 protein, mouseSestrinsTOR Serine-Threonine KinasesTRB3 protein, mouseactivating transcription factor 4 (ATF4)eukaryotic initiation factor 2 (eIF2)general control nonderepressible 2 (GCN2)hydrogen sulfideintegrated stress responselivermammalian target of rapamycin (mTOR)obesityPKR-like endoplasmic reticulum kinase (PERK)sestrin2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.