ArticleEMBO molecular medicine2017
Sodium permeable and "hypersensitive" TREK-1 channels cause ventricular tachycardia.
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Article in EMBO molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
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Who cites it
45 citing papers in PubMed, 73 citations in OpenAlex.
- Role for TREK-1 as a polymodal sensor and regulator of cell activity.Channels (Austin, Tex.) · 2026Review
- One pocket to activate them all (?): Efforts on understanding the modulator pocket in K2P channels.Channels (Austin, Tex.) · 2026Review
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- Associations Between Potassium Channel Genes and the Occurrence of Palpitations in Women Prior to Breast Cancer Surgery.Seminars in oncology nursing · 2025Article
- From Selective Permeation to Physiology in Potassium Channels.Function (Oxford, England) · 2025Review
- Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy.American journal of human genetics · 2025Article
- The two-pore KAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Unraveling the Molecular Reason of Opposing Effects of α-Mangostin and Norfluoxetine on TREK-2 at the Same Binding Site.ChemMedChem · 2024Article
- Constitutive sodium permeability in aProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Effect of two activators on the gating of a KBiophysical journal · 2024Article
- Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction.Scientific reports · 2024Article
- Electrical and Structural Insights into Right Ventricular Outflow Tract Arrhythmogenesis.International journal of molecular sciences · 2023Review
- Non-trivial dynamics in a model of glial membrane voltage driven by open potassium pores.Biophysical journal · 2023Article
- TREK channels in Mechanotransduction: a Focus on the Cardiovascular System.Frontiers in cardiovascular medicine · 2023Review
- The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism.The Journal of general physiology · 2022Article
- TREK-1 in the heart: Potential physiological and pathophysiological roles.Frontiers in physiology · 2022Review
- Distinct classes of potassium channels fused to GPCRs as electrical signaling biosensors.Cell reports methods · 2021Article
- Two-Pore-Domain Potassium (KCells · 2021Review
- Negative Influence by the Force: Mechanically Induced Hyperpolarization via KInternational journal of molecular sciences · 2021Review
- Structural Insights into the Mechanisms and Pharmacology of KJournal of molecular biology · 2021Review
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Niels DecherInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Marburg, Germany decher@staff.uni-marburg.de.ORCID 0000-0001-8892-1231
Beatriz Ortiz-BonninInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Marburg, Germany.
Corinna FriedrichDepartment of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Marcus ScheweInstitute of Physiology, Christian-Albrechts-University of Kiel, Kiel, Germany.ORCID 0000-0002-6192-5651
Aytug K KiperInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Marburg, Germany.
Susanne RinnéInstitute of Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Marburg, Germany.
Gunnar SeemannInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Center - University of Freiburg, Freiburg, Germany.
Rémi PeyronnetInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Center - University of Freiburg, Freiburg, Germany.
Sven ZumhagenDepartment of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Daniel BustosCenter for Bioinformatics and Molecular Simulation, University of Talca, Talca, Chile.
Jens KockskämperInstitute of Pharmacology and Clinical Pharmacy, Biochemical and Pharmacological Center (BPC) Philipps-University of Marburg, Marburg, Germany.
Peter KohlInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Center - University of Freiburg, Freiburg, Germany.
Steffen JustMolecular Cardiology, University Hospital Ulm, Ulm, Germany.
Wendy GonzálezCenter for Bioinformatics and Molecular Simulation, University of Talca, Talca, Chile.
Thomas BaukrowitzInstitute of Physiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Birgit StallmeyerDepartment of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Eric Schulze-BahrDepartment of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Münster, Germany.
Philipps University of Marburg · DEUniversity Hospital Münster · DEUniversity of Freiburg · DEChristian-Albrechts-Universität zu Kiel · DEUniversity of Talca · CLUniversity Hospital Ulm · DE
Funding
British Heart Foundation FS/12/17/29532
Abstract
In a patient with right ventricular outflow tract (RVOT) tachycardia, we identified a heterozygous point mutation in the selectivity filter of the stretch-activated K
Indexed as
HumansMiddle AgedMutant ProteinsPotassium Channels, Tandem Pore DomainSodiumTachycardia, VentricularMutant Proteinspotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainSodiumarrhythmiaK2PRVOTTREK‐1two‐pore domain K+ channel
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.