ArticleJournal of the American Society of Nephrology : JASN2017
Serum Uromodulin and Mortality Risk in Patients Undergoing Coronary Angiography.
Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent Advances in Urinary Peptide and Proteomic Biomarkers in Chronic Kidney Disease: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study.Journal of diabetes and its complications · 2019Trial
- Sickle Cell Disease and Kidney Injury: Circulating Uromodulin Allows Early Tissue Specific Diagnosis and Monitoring of Treatment.American journal of hematology · 2026Article
- Metabolomic Signatures of Inflammation in Chronic Kidney Disease.Kidney medicine · 2026Article
- Serum and urinary uromodulin concentration in children and young adults with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2025Article
- Advances in uromodulin biology and potential clinical applications.Nature reviews. Nephrology · 2024Review
- Insights into Uromodulin and Blood Pressure.Current hypertension reports · 2024Review
- Serum uromodulin associates with kidney function and outcome in a cohort of hospitalised COVID-19 patients.Scientific reports · 2024Article
- Relationship Between Serum Uromodulin as a Marker of Kidney Damage and Metabolic Status in Patients with Chronic Kidney Disease of Non-Diabetic Etiology.International journal of molecular sciences · 2024Article
- Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis.Frontiers in medicine · 2024Review
- The role of uromodulin in cardiovascular disease: a review.Frontiers in cardiovascular medicine · 2024Review
- Knowledge mapping of UMOD of English published work from 1985 to 2022: a bibliometric analysis.International urology and nephrology · 2024Article
- Unveiling the Hidden Power of Uromodulin: A Promising Potential Biomarker for Kidney Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Acute Toxicity and Pharmacokinetic Profile of an EU-GMP-CertifiedPharmaceuticals (Basel, Switzerland) · 2023Article
- Renal Assessment in Acute Cardiorenal Syndrome.Biomolecules · 2023Review
- The renin-angiotensin-aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Serum Uromodulin and All-Cause Mortality in Peritoneal Dialysis Patients: A Chinese Cohort Study.Kidney medicine · 2022Article
- Sepsis and Acute Kidney Injury: A Review Focusing on the Bidirectional Interplay.International journal of molecular sciences · 2022Review
- The kidney protects against sepsis by producing systemic uromodulin.American journal of physiology. Renal physiology · 2022Article
- Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality.Biomedicines · 2022Article
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6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mucoprotein uromodulin is the most abundant protein in mammalian urine and has important roles in ion transport, maintenance of water and electrolyte balance, and clearance of bacteria from the urinary tract. Low urinary uromodulin concentrations have been associated with increased mortality risk. However, measuring uromodulin in urine has several preanalytic drawbacks, and sensitive assays for the detection of uromodulin in blood have become available. In this study, we investigated the association of serum uromodulin concentration with cardiovascular biomarkers and mortality risk in a large cohort of patients referred for coronary angiography. Uromodulin concentrations were available in 3057 of 3316 participants of the Ludwigshafen Risk and Cardiovascular Health Study. Higher serum uromodulin concentration associated with a favorable metabolic profile, lower prevalence rates of comorbidities (arterial hypertension, diabetes mellitus, and heart failure), and a lower risk for 10-year mortality, with hazard ratios (95% confidence intervals) of 0.65 (0.54 to 0.78), 0.71 (0.58 to 0.88), and 0.57 (0.45 to 0.73) in the second, third, and fourth quartiles, respectively, compared with the first quartile. The association with reduced mortality was independent of other cardiovascular risk factors, including eGFR, and stronger after adjustment for the genotype of the rs12917707 polymorphism at the
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