Evidence map›Paper›PMID 28242720›Full record

ArticleJournal of bacteriology2017

Fluorescence High-Throughput Screening for Inhibitors of TonB Action.

Brittany L Nairn, Olivia S Eliasson, Dallas R Hyder, Noah J Long, Aritri Majumdar, Somnath Chakravorty, Peter McDonald, Anuradha Roy, Salete M Newton, Phillip E Klebba

Abstract read
In one paragraph

Article in Journal of bacteriology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Iron-dependent mechanisms inJAC-antimicrobial resistance · 2025
    Review
  2. Siderophore-mediated iron acquisition byJournal of bacteriology · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Analysis of SixInfection and immunity · 2022
    Article
  7. Review
  8. Review
  9. Conformational rearrangements in the N-domain ofThe Journal of biological chemistry · 2020
    Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brittany L NairnDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Olivia S EliassonDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Dallas R HyderDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Noah J LongDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Aritri MajumdarDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Somnath ChakravortyDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Peter McDonaldShankel Structural Biology Center, University of Kansas, Lawrence, Kansas, USA.
Anuradha RoyShankel Structural Biology Center, University of Kansas, Lawrence, Kansas, USA.
Salete M NewtonDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Phillip E KlebbaDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA peklebba@ksu.edu.

Funding

High-throughput fluorescence screening for inhibitors of TonB-dependent iron transportR21AI115187 · NIAID · KANSAS STATE UNIVERSITY · PI KLEBBA, PHILLIP E · 2015 to 2016
$388k
NIAID NIH HHS R21 AI115187
6 · The paper itself

Abstract

Gram-negative bacteria acquire ferric siderophores through TonB-dependent outer membrane transporters (TBDT). By fluorescence spectroscopic hgh-throughput screening (FLHTS), we identified inhibitors of TonB-dependent ferric enterobactin (FeEnt) uptake through

Indexed as

High-Throughput Screening AssaysAcinetobacter baumanniiAnti-Bacterial AgentsEscherichia coliEscherichia coli ProteinsFerric CompoundsFluorescenceMembrane ProteinsSiderophoresAnti-Bacterial AgentsEscherichia coli ProteinsFerric CompoundsMembrane ProteinsSiderophorestonB protein, E coliAcinetobacter baumanniiantibiotic resistanceESKAPE pathogenFepAferric enterobactinfluorescence assayshigh throughputiron transportTonB

Identifiers

PMID28242720
PMCPMC5405212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.