ArticleProceedings of the National Academy of Sciences of the United States of America2017
Geometric localization of thermal fluctuations in red blood cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Red Blood Cell Membrane Mechanics Using Discrete Exterior Calculus (DEC) and Optimization.International journal for numerical methods in biomedical engineering · 2026Article
- Viscoelastic phenotyping of red blood cells.Biophysical journal · 2024Article
- Measurement of red blood cell deformability during morphological changes using rotating-glass-plate-based scanning optical tweezers.Biomedical optics express · 2023Article
- Emerging Diamond Quantum Sensing in Bio-Membranes.Membranes · 2022Review
- Article
- Spatial light interference microscopy: principle and applications to biomedicine.Advances in optics and photonics · 2021Article
- Computational interference microscopy enabled by deep learning.APL photonics · 2021Article
- Large-scale simulation of biomembranes incorporating realistic kinetics into coarse-grained models.Nature communications · 2020Article
- Quantitative analysis of three-dimensional morphology and membrane dynamics of red blood cells during temperature elevation.Scientific reports · 2019Article
- Integration of diffraction phase microscopy and Raman imaging for label-free morpho-molecular assessment of live cells.Journal of biophotonics · 2019Article
- Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning.Analytical chemistry · 2019Article
- Interferometric mapping of material properties using thermal perturbation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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4 authors.
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Abstract
The thermal fluctuations of membranes and nanoscale shells affect their mechanical characteristics. Whereas these fluctuations are well understood for flat membranes, curved shells show anomalous behavior due to the geometric coupling between in-plane elasticity and out-of-plane bending. Using conventional shallow shell theory in combination with equilibrium statistical physics we theoretically demonstrate that thermalized shells containing regions of negative Gaussian curvature naturally develop anomalously large fluctuations. Moreover, the existence of special curves, "singular lines," leads to a breakdown of linear membrane theory. As a result, these geometric curves effectively partition the cell into regions whose fluctuations are only weakly coupled. We validate these predictions using high-resolution microscopy of human red blood cells (RBCs) as a case study. Our observations show geometry-dependent localization of thermal fluctuations consistent with our theoretical modeling, demonstrating the efficacy in combining shell theory with equilibrium statistical physics for describing the thermalized morphology of cellular membranes.
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