Evidence map›Paper›PMID 28242651›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2017

Metformin Suppresses Systemic Autoimmunity in

Seon-Yeong Lee, Su-Jin Moon, Eun-Kyung Kim, Hyeon-Beom Seo, Eun-Ji Yang, Hye-Jin Son, Jae-Kyung Kim, Jun-Ki Min, Sung-Hwan Park, Mi-La Cho

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
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  10. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
  11. Single-nuclei transcriptome analysis of IgMFrontiers in immunology · 2025
    Article
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Seon-Yeong LeeRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea.ORCID 0000-0003-4269-8657
Su-Jin MoonDivision of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Eun-Kyung KimRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea.
Hyeon-Beom SeoRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea.
Eun-Ji YangRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea.
Hye-Jin SonRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea.
Jae-Kyung KimRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea.
Jun-Ki MinDivision of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.
Sung-Hwan ParkDivision of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea.ORCID 0000-0003-1711-2060
Mi-La ChoRheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul 137-701, South Korea; iammila@catholic.ac.kr.
Catholic Medical Center · USCatholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating autoantibodies and immune complex deposition are pathological hallmarks of systemic lupus erythematosus (SLE). B cell differentiation into plasma cells (PCs) and some T cell subsets that function as B cell helpers can be therapeutic targets of SLE. Mechanistic target of rapamycin (mTOR) signaling is implicated in the formation of B cells and germinal centers (GCs). We assessed the effect of metformin, which inhibits mTOR, on the development of autoimmunity using

Indexed as

AMP-Activated Protein KinasesAnimalsAutoimmunityBlotting, WesternB-LymphocytesCell DifferentiationCell SeparationDisease Models, AnimalFlow CytometryGerminal CenterHypoglycemic AgentsImmunohistochemistryLupus Erythematosus, SystemicMaleMetforminMiceAMP-Activated Protein KinasesHypoglycemic AgentsMetforminmTOR protein, mouseRc3h1 protein, mouseStat3 protein, mouseSTAT3 Transcription FactorTOR Serine-Threonine KinasesUbiquitin-Protein Ligases

Identifiers

PMID28242651
PMCPMC5357783
OpenAlexW2784997505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.