ArticleArchives of gerontology and geriatrics2017
Comparison of two frailty indices in the physicians' health study.
Article in Archives of gerontology and geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Inflammation, Frailty, and Aspirin Use in the Physicians' Health Study: A Pilot Study.The Journal of frailty & aging · 2024Trial
- Trial
- Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial.JAMA network open · 2022Trial
- Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians' Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- Association between Diet Quality and Frailty Prevalence in the Physicians' Health Study.Journal of the American Geriatrics Society · 2020Trial
- Association between cardiovascular health defined by life's essential 8 and frailty among US adults: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Measuring Frailty Using Self-Report or Automated Tools to Identify Risk of Cardiovascular Events and Mortality: The Million Veteran Program.Journal of the American Heart Association · 2024Article
- Frailty and its association with long-term mortality among community-dwelling older adults aged 75 years and over.Israel journal of health policy research · 2024Article
- Feasibility of frailty screening among patients with advanced heart failure.BMJ open quality · 2023Article
- Association of Frailty With Risk of Suicide Attempt in a National Cohort of US Veterans Aged 65 Years or Older.JAMA psychiatry · 2023Article
- Evolving Hybrid Partial Genetic Algorithm Classification Model for Cost-effective Frailty Screening: Investigative Study.JMIR aging · 2022Article
- Influence of Long-term Nonaspirin NSAID Use on Risk of Frailty in Men ≥60 Years: The Physicians' Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Prevalence of Frailty and Associations with Oral Anticoagulant Prescribing in Atrial Fibrillation.Journal of general internal medicine · 2022Article
- Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The Burden of Frailty Among U.S. Veterans and Its Association With Mortality, 2002-2012.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Cross-Sectional Association of Frailty and Arterial Stiffness in Community-Dwelling Older Adults: The Framingham Heart Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS.Clinical interventions in aging · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundAs the population ages it is important to identify frailty, a powerful predictor of morbidity and mortality, and often an important unmeasured confounder. We sought to develop a frailty index in the Physician's Health Study (PHS) and estimate the association with mortality.
methodsProspective cohort study. Annual questionnaire assessed mood, function and health status. Two frailty scores were compared - cumulative deficit frailty index (PHS FI) and modified Study of Osteoporotic Fracture (mSOF) frailty score. Endpoints committee confirmed mortality.
results12,180 male physicians ≥60 years were analyzed. Mean(SD) follow-up was 10(3) years, 2168 deaths occurred. PHS FI identified 4412 (36%) physicians robust, 5305 (44%) pre-frail, and 2463 (20%) frail, while mSOF identified 7323 (61%) robust, 3505 (29%) pre-frail and 1215 (10%) frail. Age-standardized rate of death was lower among subjects identified as robust using the PHS FI, 11/1000 person-years (PY) (95% Confidence Interval (CI): 9.5-11.9) compared to 14/1000PY (95% CI: 13.5-15.4) using mSOF [P-difference <0.001]. In the prefrail group, death rates were 16/1000PY in PHS FI and 21/1000PY in mSOF, [P-difference <0.001]. There was no difference in age-adjusted mortality rates in the frail group according to each definition (35 vs 33/1000PY). Survival analysis showed an increased risk of mortality in each frailty category using either definition, (log-rank p<0.001).
conclusionThe PHS FI outperformed mSOF in identifying risk of death particularly in robust and pre-frail categories. Similar indices can be created in existing datasets to identify frail individuals and where appropriate account for frailty, an often unmeasured confounder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.