Evidence map›Paper›PMID 28242577›Full record

ArticleCancer epidemiology2017

Risk of second primary cancer associated with pre-diagnostic smoking, alcohol, and obesity in women with keratinocyte carcinoma.

Sang Min Park, Tricia Li, Shaowei Wu, Wen-Qing Li, Abrar A Qureshi, Meir Stampfer, Eunyoung Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Sang Min ParkChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Family Medicine & Department of Biomedical Sciences, Seoul National University College of Medicine, Republic of Korea.
Tricia LiDepartment of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.
Shaowei WuDepartment of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, 100191, China.
Wen-Qing LiDepartment of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA; Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
Abrar A QureshiChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA; Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA.
Meir StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Eunyoung ChoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA; Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02903, USA. Electronic address: eunyoung_cho@brown.edu.
Brigham and Women's Hospital · USBrown University · US

Funding

Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Molecular signatures of melanoma histology and progression: A Population Based AR01CA137365 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI QURESHI, ABRAR A · 2009 to 2013
$1.4M
Psoralens and melanomaR21CA198216 · NCI · BROWN UNIVERSITY · PI CHO, EUNYOUNG · 2015 to 2016
$432k
NCI NIH HHS R01 CA137365NCI NIH HHS R21 CA198216NCI NIH HHS UM1 CA186107
6 · The paper itself

Abstract

Keratinocyte carcinoma (KC), which includes basal-cell carcinoma (BCC) and squamous-cell cancer (SCC), has been associated with an increased risk of second primary cancers (SPCs), although the reason for this increase is unknown. We assessed the effects of smoking, alcohol, and obesity prior to the diagnosis of KC on the development of SPCs, as these are well-established risk factors for multiple cancers and may also contribute to the increased risk of SPCs among those with KC. A total of 15,628 women with self-reported KC were identified in the Nurses' Health Study. Incident SPCs were assessed throughout the follow-up until June 2012. Cox proportional hazards models were used to calculate the hazard ratios (HRs) of SPC associated with pre-diagnostic smoking, alcohol and body mass index (BMI). We also compared these risk estimates to those for first cancers in all cohort participants. During 193,695 person-years of follow-up, we recorded 2839 SPC cases. Compared with never smokers, current smokers had a significantly elevated risk for SPC overall and specifically for lung, colorectal, and bladder cancers. We also found a positive association between higher BMI and risk for SPC overall as well as for endometrial and bladder SPCs. Women with KC who consumed alcohol ≥30g/day had a marginally higher risk of SPC compared to non-drinkers. The associations between incident SPC risk among KC cases and smoking, alcohol, and obesity appeared similar to the associations between these risk factors and the incident first primary cancers in the whole cohort. Only in the heavy smoking (≥25 cigarettes/day) category was the HR for SPC after KC (2.34; 95% CI 1.98-2.76) slightly higher than that for the first cancer in the overall cohort (HR 1.86; 95% CI 1.75-1.98, P

Indexed as

AdultAlcohol DrinkingBasal Cell CarcinomaBody Mass IndexCarcinoma, Squamous CellFemaleHumansKeratinocytesMiddle AgedNeoplasms, Second PrimaryObesityProportional Hazards ModelsProspective StudiesRisk FactorsSkin NeoplasmsSmokingAlcoholBody mass indexKeratinocyte carcinomaSecond primary cancerSmoking

Identifiers

PMID28242577
PMCPMC5937268
OpenAlexW2590348737

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.