ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2017
Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
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- Predicting long-term progression of Alzheimer's disease using a multimodal deep learning model incorporating interaction effects.Journal of translational medicine · 2024Article
- Novel cuproptosis metabolism-related molecular clusters and diagnostic signature for Alzheimer's disease.Frontiers in molecular biosciences · 2024Article
- Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies.Molecular neurodegeneration · 2023Review
- Amyloid-β Pathology-Specific Cytokine Secretion Suppresses Neuronal Mitochondrial Metabolism.Cellular and molecular bioengineering · 2023Article
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- Identification of diagnostic biomarkers in Alzheimer's disease by integrated bioinformatic analysis and machine learning strategies.Frontiers in aging neuroscience · 2023Article
- Modeling Alzheimer's Disease inBiomedicines · 2022Review
- Shared genetic architecture between the two neurodegenerative diseases: Alzheimer's disease and glaucoma.Frontiers in aging neuroscience · 2022Article
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- Dynamic Interplay between Copper Toxicity and Mitochondrial Dysfunction in Alzheimer's Disease.Life (Basel, Switzerland) · 2021Review
- Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach.Scientific reports · 2021Article
- Review
- The new genetic landscape of Alzheimer's disease: from amyloid cascade to genetically driven synaptic failure hypothesis?Acta neuropathologica · 2019Review
- Identifying and ranking potential driver genes of Alzheimer's disease using multiview evidence aggregation.Bioinformatics (Oxford, England) · 2019Article
- Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenicDisease models & mechanisms · 2019Article
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
introductionWe sought to determine whether a systems biology approach may identify novel late-onset Alzheimer's disease (LOAD) loci.
methodsWe performed gene-wide association analyses and integrated results with human protein-protein interaction data using network analyses. We performed functional validation on novel genes using a transgenic Caenorhabditis elegans Aβ proteotoxicity model and evaluated novel genes using brain expression data from people with LOAD and other neurodegenerative conditions.
resultsWe identified 13 novel candidate LOAD genes outside chromosome 19. Of those, RNA interference knockdowns of the C. elegans orthologs of UBC, NDUFS3, EGR1, and ATP5H were associated with Aβ toxicity, and NDUFS3, SLC25A11, ATP5H, and APP were differentially expressed in the temporal cortex. DISCUSSION: Network analyses identified novel LOAD candidate genes. We demonstrated a functional role for four of these in a C. elegans model and found enrichment of differentially expressed genes in the temporal cortex.
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