Evidence map›Paper›PMID 28241454›Full record

ArticleInternational journal of molecular sciences2017

Next-Generation Sequencing Approach in Methylation Analysis of HNF1B and GATA4 Genes: Searching for Biomarkers in Ovarian Cancer.

Ivana Bubancova, Helena Kovarikova, Jan Laco, Ema Ruszova, Ondrej Dvorak, Vladimir Palicka, Marcela Chmelarova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
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  7. Article
  8. Article
  9. Article
  10. Cross-Cancer Pleiotropic Associations with Lung Cancer Risk in African Americans.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Article
  11. Article
  12. Aberrant methylation of PCDH17 gene in high-grade serous ovarian carcinoma.Cancer biomarkers : section A of Disease markers · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ivana BubancovaInstitute of Clinical Biochemistry and Diagnostics, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. ivana.bubancova@fnhk.cz.
Helena KovarikovaInstitute of Clinical Biochemistry and Diagnostics, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. kovarikovahe@lfhk.cuni.cz.
Jan LacoThe Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. lacoj@lfhk.cuni.cz.
Ema RuszovaDepartment of Clinical Genetics, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. ema.ruszova@fnhk.cz.
Ondrej DvorakDepartment of Obstetrics and Gynecology, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. ondrej.dvorak@fnhk.cz.
Vladimir PalickaInstitute of Clinical Biochemistry and Diagnostics, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. palicka@lfhk.cuni.cz.
Marcela ChmelarovaInstitute of Clinical Biochemistry and Diagnostics, Charles University Faculty of Medicine and University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic. marcela.chmelarova@fnhk.cz.
Charles University · CZUniversity Hospital Hradec Králové · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation is well-known to be associated with ovarian cancer (OC) and has great potential to serve as a biomarker in monitoring response to therapy and for disease screening. The purpose of this study was to investigate methylation of

Indexed as

Biomarkers, TumorDNA MethylationAdultAgedFemaleFollow-Up StudiesGATA4 Transcription FactorGene Expression Regulation, NeoplasticHepatocyte Nuclear Factor 1-betaHigh-Throughput Nucleotide SequencingHumansKaplan-Meier EstimateMiddle AgedNeoplasm GradingNeoplasm StagingOvarian NeoplasmsBiomarkers, TumorGATA4 Transcription FactorHepatocyte Nuclear Factor 1-betabiomarkerGATA4HNF1Bmethylationnext-generation sequencingovarian cancer

Identifiers

PMID28241454
PMCPMC5344006
OpenAlexW2589306644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.