Evidence map›Paper›PMID 28241420›Full record

Trial reportNutrients2017

Antiosteoporotic Activity of Genistein Aglycone in Postmenopausal Women: Evidence from a Post-Hoc Analysis of a Multicenter Randomized Controlled Trial.

Vincenzo Arcoraci, Marco Atteritano, Francesco Squadrito, Rosario D'Anna, Herbert Marini, Domenico Santoro, Letteria Minutoli, Sonia Messina, Domenica Altavilla, Alessandra Bitto

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Isoflavone intervention and its impact on bone mineral density in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Vincenzo ArcoraciDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. varcoraci@unime.it.
Marco AtteritanoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. matteritano@unime.it.
Francesco SquadritoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. fsquadrito@unime.it.
Rosario D'AnnaDepartment of Neurosciences and Nemo Sud Clinical Center, University of Messina, 98100 Messina, Italy. rdannna@unime.it.
Herbert MariniDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. hrmarini@unime.it.
Domenico SantoroDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. santisi@hotmail.com.
Letteria MinutoliDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. lminutoli@unime.it.
Sonia MessinaDepartment of Neurosciences and Nemo Sud Clinical Center, University of Messina, 98100 Messina, Italy. smessina@unime.it.
Domenica AltavillaDepartment of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, 98100 Messina, Italy. daltavilla@unime.it.
Alessandra BittoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy. abitto@unime.it.
University of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genistein has a preventive role against bone mass loss during menopause. However, experimental data in animal models of osteoporosis suggest an anti-osteoporotic potential for this isoflavone. We performed a post-hoc analysis of a previously published trial investigating the effects of genistein in postmenopausal women with low bone mineral density. The parent study was a randomized, double-blind, placebo-controlled trial involving postmenopausal women with a femoral neck (FN) density <0.795 g/cm². A cohort of the enrolled women was, in fact, identified at the baseline as osteoporotic (

Indexed as

PostmenopauseBone DensityBone Density Conservation AgentsCalcium, DietaryCholecalciferolDouble-Blind MethodFemaleFemur NeckGenisteinHip FracturesHumansOsteoporosis, PostmenopausalPhytoestrogensPlacebosRiskRisk AssessmentBone Density Conservation AgentsCalcium, DietaryCholecalciferolGenisteinPhytoestrogensPlacebosbone mineral densitygenisteinpostemenopausal osteoporosis

Identifiers

PMID28241420
PMCPMC5331610
OpenAlexW2590340550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.