ArticleHippocampus2017
Hippocampal neural activity reflects the economy of choices during goal-directed navigation.
Article in Hippocampus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of affective touch in mental illness: a systematic review of CT fiber dysregulation in psychological disorders and the therapeutic potential of CT fiber stimulation.Frontiers in psychiatry · 2025Pooled it
- Flexible navigation with neuromodulated cognitive maps.PLoS computational biology · 2026Article
- The relevance of context in memory tasks influences the magnitude of hippocampal remapping.Cell reports · 2025Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation.Nature metabolism · 2025Article
- Minocycline prevents early age-related cognitive decline in a mouse model of intellectual disability caused by ZBTB18/RP58 haploinsufficiency.Journal of neuroinflammation · 2024Article
- Remapping revisited: how the hippocampus represents different spaces.Nature reviews. Neuroscience · 2024Review
- Navigation and the efficiency of spatial coding: insights from closed-loop simulations.Brain structure & function · 2024Article
- Learning to predict future locations with internally generated theta sequences.PLoS computational biology · 2023Article
- Neural circuit dynamics of drug-context associative learning in the mouse hippocampus.Nature communications · 2022Article
- Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal.Nature communications · 2022Article
- Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu-opioid receptor.MedComm · 2022Review
- Space, feature, and risk sensitivity in homing pigeons (Columba livia): Broadening the conversation on the role of the avian hippocampus in memory.Learning & behavior · 2022Article
- Adapting hippocampus multi-scale place field distributions in cluttered environments optimizes spatial navigation and learning.Frontiers in computational neuroscience · 2022Article
- Navigating for reward.Nature reviews. Neuroscience · 2021Review
- Do hippocampal pyramidal cells respond to nonspatial stimuli?Physiological reviews · 2021Review
- Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats.Clocks & sleep · 2021Article
- The hippocampus encodes delay and value information during delay-discounting decision making.eLife · 2020Article
- Insensitivity of Place Cells to the Value of Spatial Goals in a Two-Choice Flexible Navigation Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neural Representation of Overlapping Path Segments and Reward Acquisitions in the Monkey Hippocampus.Frontiers in systems neuroscience · 2019Article
Corrections and comments
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6 authors.
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Abstract
Distinguishing spatial contexts is likely essential for the well-known role of the hippocampus in episodic memory. We studied whether types of hippocampal neural organization thought to underlie context discrimination are impacted by learned economic considerations of choice behavior. Hippocampal place cells and theta activity were recorded as rats performed a maze-based probability discounting task that involved choosing between a small certain reward or a large probabilistic reward. Different spatial distributions of place fields were observed in response to changes in probability, the outcome of the rats' choice, and whether or not rats were free to make that choice. The degree to which the reward location was represented by place cells scaled with the expected probability of rewards. Theta power increased around the goal location also in proportion to the expected probability of signaled rewards. Furthermore, theta power dynamically varied as specific econometric information was obtained "on the fly" during task performance. Such an economic perspective of memory processing by hippocampal place cells expands our view of the nature of context memories retrieved by hippocampus during adaptive navigation.
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