ArticleJournal of biomedical optics2017
Miniature spectral imaging device for wide-field quantitative functional imaging of the morphological landscape of breast tumor margins.
Article in Journal of biomedical optics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Force-regulated robotic diffuse reflectance spectroscopy scanning.Journal of biomedical optics · 2026Article
- Emerging and future use of intra-surgical volumetric X-ray imaging and adjuvant tools for decision support in breast-conserving surgery.Current opinion in biomedical engineering · 2022Article
- Quantitative assessment of distant recurrence risk in early stage breast cancer using a nonlinear combination of pathological, clinical and imaging variables.Journal of biophotonics · 2020Article
- Methods of extraction of optical properties from diffuse reflectance measurements of ex-vivo human colon tissue using thin film silicon photodetector arrays.Biomedical optics express · 2019Article
- Intra-operative spectroscopic assessment of surgical margins during breast conserving surgery.Breast cancer research : BCR · 2018Article
- Quantitative characterization of turbidity by radiative transfer based reflectance imaging.Biomedical optics express · 2018Article
- Multiscale nonlinear microscopy and widefield white light imaging enables rapid histological imaging of surgical specimen margins.Biomedical optics express · 2018Article
- Automated detection of breast cancer in resected specimens with fluorescence lifetime imaging.Physics in medicine and biology · 2017Article
- Evaluating feasibility of an automated 3-dimensional scanner using Raman spectroscopy for intraoperative breast margin assessment.Scientific reports · 2017Article
- Flexible silicon sensors for diffuse reflectance spectroscopy of tissue.Biomedical optics express · 2017Article
- Improved Margins Detection of Regions Enriched with Gold Nanoparticles inside Biological Phantom.Materials (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We have developed a portable, breast margin assessment probe leveraging diffuse optical spectroscopy to quantify the morphological landscape of breast tumor margins during breast conserving surgery. The approach presented here leverages a custom-made 16-channel annular photodiode imaging array (arranged in a 4 × 4 grid), a raster-scanning imaging platform with precision pressure control, and compressive sensing with an optimized set of eight wavelengths in the visible spectral range. A scalable Monte-Carlo-based inverse model is used to generate optical property [ ? s ? ( ? ) and ? a ( ? ) ] measures for each of the 16 simultaneously captured diffuse reflectance spectra. Subpixel sampling (0.75 mm) is achieved through incremental x , y raster scanning of the imaging probe, providing detailed optical parameter maps of breast margins over a 2 × 2 ?? cm 2 area in ? 9 ?? min . The morphological landscape of a tumor margin is characterized using optical surrogates for the fat to fibroglandular content ratio, which has demonstrated diagnostic utility in delineating tissue subtypes in the breast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.