Evidence map›Paper›PMID 28241208›Full record

ArticleJAMA oncology2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Telomeres Mendelian Randomization Collaboration, Philip C Haycock, Stephen Burgess, Aayah Nounu, Jie Zheng, George N Okoli, Jack Bowden, Kaitlin Hazel Wade, Nicholas J Timpson, David M Evans and 189 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 353 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
353citing papers in PubMed, 13 pooled it
33.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

353 citing papers in PubMed, 13 syntheses or guidelines pooled it, 522 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Telomere Length and Hearing Loss: A Two-Sample Mendelian Randomization.International journal of environmental research and public health · 2022
    Pooled it
  10. Pooled it
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  13. Pooled it
  14. Trial
  15. Trial
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Review

293 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

199 authors at 20 institutions in 22 countries.

Telomeres Mendelian Randomization Collaboration
Philip C HaycockMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Stephen BurgessDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, England.
Aayah NounuMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Jie ZhengMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
George N OkoliSchool of Social and Community Medicine, University of Bristol, Bristol, England.
Jack BowdenMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Kaitlin Hazel WadeMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Nicholas J TimpsonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
David M EvansMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England4University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland, Australia.
Peter WilleitDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, England5Department of Neurology, Innsbruck Medical University, Austria.
Abraham AvivCenter of Human Development and Aging, Department of Pediatrics, New Jersey Medical School, Rutgers, The State University of New Jersey.
Tom R GauntMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Gibran HemaniMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London England8NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, England.
Hayley Patricia EllisBrain Tumour Research Group, Institute of Clinical Neuroscience, Learning and Research Building, Southmead Hospital, University of Bristol.
Kathreena M KurianBrain Tumour Research Group, Institute of Clinical Neuroscience, Learning and Research Building, Southmead Hospital, University of Bristol.
Karen A PooleyCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
Rosalind A EelesThe Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, England.
Jeffrey E LeeDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
Shenying FangDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston.
Wei V ChenDepartment of Clinical Applications & Support, The University of Texas MD Anderson Cancer Center, Houston.
Matthew H LawStatistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Lisa M BowdlerQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mark M IlesSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, England.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Bradford B WorrallDepartments of Neurology and Public Health Sciences, University of Virginia Charlottesville, Virginia.
Hugh Stephen MarkusDepartment of Clinical Neurosciences, University of Cambridge, England.
Rayjean J HungLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada21Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Chris I AmosGeisel School of Medicine, Dartmouth College, Hanover, New Hampshire.
Amanda B SpurdleGenetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, England.
Tracy A O'MaraGenetics and Computational Biology Division, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Brian WolpinDana-Farber Cancer Institute, Boston, Massachusetts.
Laufey AmundadottirLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Rachael Stolzenberg-SolomonMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece28WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
N Charlotte Onland-MoretDepartment of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands.
Eiliv LundInstitute of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway.
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gianluca SeveriUniversité Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France34Institut Gustave Roussy, Villejuif, France35Human Genetics Foundation (HuGeF), Torino, Italy36Cancer Council Victoria and University of Melbourne, Melbourne, Australia.
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark.
Marc J GunterSchool of Public Health, Imperial College London, London, England.
Rosario TuminoCancer Registry, Azienda Ospedaliera "Civile M.P. Arezzo," Ragusa, Italy.
Ulrika SvensonDepartment of Medical Biosciences, Umea University, Umea, Sweden.
Andre van RijSurgery Department, University of Otago, Dunedin, New Zealand.
Annette F BaasDepartment of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Matthew J BownDepartment of Cardiovascular Sciences and the NIHR Leicester, Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester, England.
Nilesh J SamaniDepartment of Cardiovascular Sciences and the NIHR Leicester, Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester, England.
Femke N G van t'HofDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.
Gerard TrompDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa46The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania.
Gregory T JonesSurgery Department, University of Otago, Dunedin, New Zealand.
Helena KuivaniemiDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa46The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania.
James R ElmoreDepartment of Vascular and Endovascular Surgery, Geisinger Health System, Danville, Pennsylvania.
Mattias JohanssonGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
James MckayGenetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France.
Ghislaine SceloGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Robert Carreras-TorresGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Valerie GaborieauGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Paul BrennanGenetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco.
Rachel E NealeQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven GallingerLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Donghui LiDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston.
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Harvey A RischYale School of Public Health, Yale School of Medicine, and Yale Cancer Center, New Haven, Connecticut.
Alison P KleinDepartments of Oncology, Pathology and Epidemiology, Johns Hopkins School of Medicine, Baltimore, Maryland.
Jiali HanDepartment of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis57Indiana University Melvin and Bren Simon Cancer Center, Indianapolis.
Christian C AbnetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Philip R TaylorDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
John M MarisChildren's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania.
Katja K AbenRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands61Netherlands Comprehensive Cancer Organization, Utrecht, The Netherlands.
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Sita H VermeulenRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
John K WienckeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California63Institute of Human Genetics, University of California, San Francisco, San Francisco, California.
Kyle M WalshDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California63Institute of Human Genetics, University of California, San Francisco, San Francisco, California.
Margaret WrenschDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California63Institute of Human Genetics, University of California, San Francisco, San Francisco, California.
Terri RiceDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California.
Clare TurnbullThe Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, England64William Harvey Research Institute, Queen Mary University, London, England.
Kevin LitchfieldDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, England.
Lavinia PaternosterMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Marie StandlInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Gonçalo R AbecasisDepartment of Biostatistics, University of Michigan, Ann Arbor.
John Paul SanGiovanniNational Institute of Alcohol Abuse and Alcoholism, Laboratory of Membrane Biophysics and Biochemistry, Section on Nutritional Neuroscience, Bethesda, Maryland69Department of Biochemistry and Molecular and Cellular Biology, Georgetown School of Medicine, Washington, DC.
Yong LiDivision of Genetic Epidemiology, Institute for Medical Biometry and Statistics, Faculty of Medicine, and Medical Centre, University of Freiburg, Freiburg, Germany.
Vladan MijatovicDepartment of Life and Reproduction Sciences, University of Verona, Verona, Italy.
Yadav SapkotaQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Siew-Kee LowLaboratory of Statistical Analysis, Centre for Integrative Medical Sciences, The Institute of Physical and Chemical Research (RIKEN), Yokohama, Japan.
Krina T ZondervanGenetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England74Nuffield Department of Obstetrics and Gynecology, University of Oxford, John Radcliffe Hospital, Oxford, England.
Grant W MontgomeryQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Dale R NyholtQIMR Berghofer Medical Research Institute, Brisbane, Australia75Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
David A van HeelBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, England.
Karen HuntBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, England.
Dan E ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Foram N AsharMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Nona SotoodehniaDivision of Cardiology and Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Daniel WooUniversity of Cincinnati College of Medicine, Department of Neurology, Cincinnati, Ohio.
Jonathan RosandMassachusetts General Hospital, Neurology, Center for Human Genetic Research, Boston, Massachusetts.
Mary E ComeauCenter for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
W Mark BrownCenter for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Edwin K SilvermanChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Jennie HuiBusselton Population Medical Research Institute Inc, Sir Charles Gairdner Hospital, Perth, Australia85PathWest Laboratory Medicine of Western Australia, Perth, Australia86School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia87School of Population Health, University of WA, Perth, Australia.
Manuel A FerreiraQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Philip J ThompsonThe Lung Health Clinic and Institute for Respiratory Health, University of Western Australia, Perth, Australia.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, Houston.
Janine F FelixDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle.
Angela M ChristianoDepartments of Dermatology and Genetics & Development, Columbia University, New York, New York.
Lynn PetukhovaDepartments of Dermatology and Epidemiology, Columbia University, New York, New York.
Regina C BetzInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Xing FanInstitute of Dermatology & Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xuejun ZhangInstitute of Dermatology & Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Caihong ZhuInstitute of Dermatology & Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Carl D LangefeldCenter for Public Health Genomics, Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Susan D ThompsonCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Feijie WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
David A SchwartzDepartment of Medicine, School of Medicine, University of Colorado, Aurora.
Tasha FingerlinDepartment of Biomedical Research, National Jewish Health Hospital, Denver, Colorado.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California101Departments of Pediatrics and Medicine, Harbor-UCLA Medical Center, Torrance, California.
Mary Frances CotchEpidemiology Branch, Division of Epidemiology and Clinical Applications, Intramural Research Program, National Eye Institute, National Institutes of Health, Clinical Research Center, Bethesda, Maryland.
Richard A JensenCardiovascular Health Research Unit, University of Washington, Seattle104Department of Medicine, University of Washington, Seattle.
Matthias MunzDepartment of Periodontology and Synoptic Dentistry, Center for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany106Institute for Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
Henrik DommischDepartment of Periodontology and Synoptic Dentistry, Center for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany.
Arne S SchaeferDepartment of Periodontology and Synoptic Dentistry, Center for Dental and Craniofacial Sciences, Charité - University Medicine Berlin, Berlin, Germany.
Fang HanDepartment of Pulmonary Medicine, Peking University People's Hospital, Beijing, China.
Hanna M OllilaStanford University, Center for Sleep Sciences, Palo Alto, California.
Ryan P HillaryStanford University, Center for Sleep Sciences, Palo Alto, California.
Omar AlbaghaQatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar110Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
Stuart H RalstonCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
Chenjie ZengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Andre ReisInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Steffen UebeInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Ulrike HüffmeierInstitute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Yoshiya KawamuraDepartment of Psychiatry, Shonan Kamakura General Hospital, Kanagawa, Japan.
Takeshi OtowaDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan115Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology, Tokyo, Japan.
Tsukasa SasakiDepartment of Physical and Health Education, Graduate School of Education, University of Tokyo, Tokyo, Japan.
Martin Lloyd HibberdInfectious Diseases, Genome Institute of Singapore, Singapore.
Sonia DavilaHuman Genetics, Genome Institute of Singapore, Singapore.
Gang XieLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada119Departments of Medicine, Immunology, Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Katherine SiminovitchLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada119Departments of Medicine, Immunology, Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Jin-Xin BeiSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Yi-Xin ZengSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China121Peking Union Medical College, Beijing, China.
Asta FörstiMolecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany123Center for Primary Health Care Research, Clinical Research Center, Lund University, Malmö, Sweden.
Bowang ChenMolecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefano LandiDepartment of Biology, University of Pisa, Pisa, Italy.
Andre FrankeUniversity Hospital Schleswig-Holstein, Kiel, Germany.
Annegret FischerUniversity Hospital Schleswig-Holstein, Kiel, Germany126Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
David EllinghausInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Carlos FloresResearch Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Tenerife, Spain128CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Imre NothSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Shwu-Fan MaSection of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois.
Jia Nee FooHuman Genetics, Genome Institute of Singapore, A*STAR, Singapore.
Jianjun LiuHuman Genetics, Genome Institute of Singapore, A*STAR, Singapore.
Jong-Won KimDepartment of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan, University School of Medicine, Gangnam-gu, Seoul, South Korea.
David G CoxCancer Research Center of Lyon, INSERM U1052, Lyon, France.
Olivier DelattreInserm U830, Institut Curie, PSL University, Paris, France.
Olivier MirabeauInserm U830, Institut Curie, PSL University, Paris, France.
Christine F SkibolaDepartment of Epidemiology, University of Alabama at Birmingham.
Clara S TangDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Merce Garcia-BarceloDepartment of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Kai-Ping ChangDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Lin-Kou, Taoyuan, Taiwan.
Wen-Hui SuDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital at Lin-Kou, Taoyuan, Taiwan137Department of Biomedical Sciences, Graduate Institute of Biomedical Sciences, College of Medicine, Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Yu-Sun ChangMolecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Scott GordonQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Tracey D WadeSchool of Psychology, Flinders University, Adelaide, South Australia.
Chaeyoung LeeSchool of Systems Biomedical Science, Soongsil University, Dongjak-gu, Seoul, South Korea.
Michiaki KuboRIKEN Center for Integrative Medical Science, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan.
Pei-Chieng ChaDivision of Molecular Brain Science, Kobe University Graduate School of Medicine, Kusunoki-chou, Chuo-ku, Kobe, Japan.
Yusuke NakamuraCenter for Personalized Therapeutics, The University of Chicago, Chicago, Illinois.
Daniel LevyThe NHLBI's Framingham Heart Study, Framingham, Massachusetts, Population Sciences Branch of the National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Masayuki KimuraCenter of Human Development and Aging, Department of Pediatrics, New Jersey Medical School, Rutgers, The State University of New Jersey.
Shih-Jen HwangThe NHLBI's Framingham Heart Study, Framingham, Massachusetts, Population Sciences Branch of the National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Steven HuntDepartment of Genetic Medicine, Weill Cornell Medicine in Qatar, Doha, Qatar.
Tim SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London England.
Nicole SoranzoHuman Genetics, Wellcome Trust Sanger Institute, Genome Campus, Hinxton Cambridge, England.
Ani W ManichaikulCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville.
R Graham BarrDepartment of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, New York.
Bratati KahaliDepartment of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor.
Elizabeth SpeliotesDepartment of Internal Medicine, Division of Gastroenterology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor.
Laura M Yerges-ArmstrongDepartment of Medicine, University of Maryland, Baltimore.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Center, Singapore152Department of Ophthalmology, National University of Singapore and National University Health System, Singapore153Duke-NUS Medical School, Singapore.
Jost B JonasBeijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China155Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Center, Singapore152Department of Ophthalmology, National University of Singapore and National University Health System, Singapore153Duke-NUS Medical School, Singapore.
Isabella FoghDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Kuang LinDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
John F PowellDepartment of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle.
Caroline L ReltonMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
Richard M MartinMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England158University of Bristol/University Hospitals Bristol NHS Foundation Trust National Institute for Health Research Bristol Nutrition Biomedical Research Unit, Bristol, England.
George Davey SmithMRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.
University of Bristol · GBQIMR Berghofer Medical Research Institute · AUCentre International de Recherche sur le Cancer · FRThe University of Texas MD Anderson Cancer Center · USUniversity of Cambridge · GBUniversity of Washington · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGeisinger Health System · USGenome Institute of Singapore · SGJohns Hopkins University · USKing's College London · GBMount Sinai Hospital · CANeurological Surgery · USNorth Carolina Division of Public Health · USUniversity Medical Center Utrecht · NLUniversity of Chicago · USUniversity of Michigan–Ann Arbor · USVanderbilt University Medical Center · USBrigham and Women's Hospital · USChang Gung Memorial Hospital · TW

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M. · 2004 to 2018
$32.7M
Mechanisms of Familial Pulmonary FibrosisP01HL092870 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLACKWELL, TIMOTHY S. · 2010 to 2020
$21.6M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF)R01HL097163 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FINGERLIN, TASHA E., SCHWARTZ, DAVID ALBERT · 2009 to 2018
$16.4M
Whole Genome Scan in the Pancreatic Cancer Cohort Consortium (PanScan)ZIACP010193 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI STOLZENBERG-SOLOMON, RACHAEL · 2009 to 2025
$9.5M
British Heart Foundation RG/08/014/24067Cancer Research UK 16563Cancer Research UK 19167Cancer Research UK 19169Cancer Research UK 20138Intramural NIH HHS Z01 EY000403Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000403Medical Research Council G0700491Medical Research Council G1001158Medical Research Council MC_EX_MR/L012286/1Medical Research Council MC_UU_00002/7Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/3Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12013/8Medical Research Council MR/L003120/1Medical Research Council MR/M012816/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS P30 CA023108NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA052689NCI NIH HHS UM1 CA182883NHGRI NIH HHS U01 HG006382NHLBI NIH HHS P01 HL092870NHLBI NIH HHS R01 HL064310NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R33 HL120770NIAMS NIH HHS P30 AR047363NIAMS NIH HHS P30 AR070549NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK106621NIDDK NIH HHS R01 DK107904NIGMS NIH HHS P20 GM103534NINDS NIH HHS T32 NS047996Wellcome Trust 202802/Z/16/ZWellcome Trust 204623/Z/16/ZWorld Health Organization 001
6 · The paper itself

Abstract

importanceThe causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation.

objectiveTo conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES: Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION: GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS: Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES: Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation.

resultsSummary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE: It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.

Indexed as

AdultAgedAged, 80 and overCardiovascular DiseasesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGerm-Line MutationHumansMaleMendelian Randomization AnalysisMiddle AgedNeoplasmsPolymorphism, Single NucleotideRisk AssessmentTelomere

Identifiers

PMID28241208
PMCPMC5638008
OpenAlexW2592294322

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