Evidence map›Paper›PMID 28241096›Full record

ArticleCancer2017

The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer.

Carole Fakhry, William H Westra, Steven J Wang, Annemieke van Zante, Yuehan Zhang, Eleni Rettig, Linda X Yin, William R Ryan, Patrick K Ha, Alicia Wentz and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 4 pooled it
27.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 4 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Radio(chemo)therapy in anal cancer: evaluation of sex-specific disparities across AJCC stages.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  8. Sex influences on tumor innervation.Biology of sex differences · 2026
    Article
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Carole FakhryHead and Neck Surgery, Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland.
William H WestraDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Steven J WangHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
Annemieke van ZanteDepartment of Pathology, University of California San Francisco, San Francisco, California.
Yuehan ZhangDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
Eleni RettigHead and Neck Surgery, Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland.
Linda X YinHead and Neck Surgery, Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland.
William R RyanHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
Patrick K HaHead and Neck Surgery, Department of Otolaryngology, University of California San Francisco, San Francisco, California.
Alicia WentzDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
Wayne KochHead and Neck Surgery, Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland.
Jeremy D RichmonHead and Neck Surgery, Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland.
David W EiseleHead and Neck Surgery, Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland.
Gypsyamber D'SouzaDepartment of Epidemiology, Johns Hopkins University, Baltimore, Maryland.
Johns Hopkins University · USUniversity of California, San Francisco · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 2007 to 2016
$27.1M
NCI NIH HHS P30 CA006973NIDCR NIH HHS P50 DE019032
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers (HNSCCs).

methodsThis retrospective, multi-institution study included OPSCCs and non-OP HNSCCs of the oral cavity, larynx, and nasopharynx diagnosed from 1995 to 2012. Race/ethnicity was categorized as white non-Hispanic, black non-Hispanic, Asian non-Hispanic, and Hispanic of any race. Tumors were centrally tested for p16 overexpression and the presence of HPV by HPV16 DNA and high-risk HPV E6/E7 messenger RNA in situ hybridization. Kaplan-Meier and Cox proportional hazards models were used to evaluate overall survival (OS).

resultsThe study population included 239 patients with OPSCC and 621 patients with non-OP HNSCC with a median follow-up time of 3.5 years. After adjustments for the tumor HPV status, age, current tobacco use, and stage, the risk of death was lower for women versus men with OPSCC (adjusted hazard ratio, 0.55; P = .04). The results were similar with p16. In contrast, for non-OP HNSCCs, HPV positivity, p16 positivity, and sex were not associated with OS.

conclusionsFor OPSCC, there are differences in survival by sex, even after the tumor HPV status has been taken into account. For non-OP HNSCC, the HPV status and the p16 status are not of prognostic significance. Cancer 2017;123:1566-1575. © 2017 American Cancer Society.

Indexed as

AsianBlack or African AmericanCarcinoma, Squamous CellCyclin-Dependent Kinase Inhibitor p16DNA, ViralEthnicityFemaleHead and Neck NeoplasmsHispanic or LatinoHuman papillomavirus 16HumansLaryngeal NeoplasmsMaleMouth NeoplasmsNasopharyngeal NeoplasmsNeoplasm StagingCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16DNA, ViralE6 protein, Human papillomavirus type 16oncogene protein E7, Human papillomavirus type 16Oncogene Proteins, ViralPapillomavirus E7 ProteinsRepressor Proteinshead and neck squamous cell cancer (HNSCC)human papillomavirus (HPV)oropharyngeal squamous cell cancer (OPSCC)p16prognosisracesex

Identifiers

PMID28241096
PMCPMC5788020
OpenAlexW2591834340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.