Evidence map›Paper›PMID 28241094›Full record

ArticleCancer2017

Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area.

Zhiwei Liu, Ellen T Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  18. A Systematic Review on Clinico-Aetiopathological Trends of Nasopharyngeal Cancer in Asia.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Zhiwei LiuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Ellen T ChangExponent Inc, Health Sciences Practice, Menlo Park, California.
Qing LiuDepartment of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Yonglin CaiDepartment of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi, China.
Zhe ZhangDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Guomin ChenState Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Qi-Hong HuangSihui Cancer Institute Sihui, Guangdong, China.
Shang-Hang XieDepartment of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Su-Mei CaoDepartment of Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Jian-Yong ShaoState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Wei-Hua JiaState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Yuming ZhengDepartment of Clinical Laboratory, Wuzhou Red Cross Hospital, Wuzhou, Guangxi, China.
Jian LiaoCangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, Guangxi, China.
Yufeng ChenKey Laboratory of High-Incidence Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, China.
Longde LinKey Laboratory of High-Incidence Tumor Prevention and Treatment, Guangxi Medical University, Ministry of Education, Nanning, Guangxi, China.
Liming LiangDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Ingemar ErnbergDepartment of Microbiology, Tumor and Cell Biology Karolinska Institute, Stockholm, Sweden.
Thomas L VaughanPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Hans-Olov AdamiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Guangwu HuangDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Yi ZengState Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yi-Xin ZengState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
Weimin YeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Funding

Gene-environment EBV Interactions in the Etiology of Nasopharyngeal Carcinoma (NPR01CA115873 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI ADAMI, HANS-OLOV · 2008 to 2013
$2.4M
NCI NIH HHS R01 CA115873
6 · The paper itself

Abstract

backgroundTo the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations.

methodsThe authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC. In addition, the authors compiled a reconstructed cohort comprising 40,781 first-degree relatives of cases and controls to calculate the lifetime cumulative risk of NPC.

resultsIndividuals with a first-degree family history of NPC were found to be at a >4-fold risk of NPC (OR, 4.6; 95% CI, 3.5-6.1) compared with those without such a history, but had no excess risk of other malignancies. The excess risk was higher for a maternal than a paternal history and was slightly stronger for a sibling compared with a parental history, and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of NPC up to age 74 years was 3.7% (95% CI, 3.3%-4.2%), whereas that among relatives of controls was 0.9% (95% CI, 0.7%-1.2%). Cumulative risk was higher in siblings than in parents among relatives of cases, whereas no such difference was noted among relatives of controls.

conclusionsIndividuals with a family history of NPC have a substantially higher risk of NPC. These relative and cumulative risk estimates can guide the development of strategies for early detection and clinical consultation in populations with a high incidence of NPC. Cancer 2017;123:2716-25. © 2017 American Cancer Society.

Indexed as

AdultAgedCarcinomaCase-Control StudiesChinaCohort StudiesFemaleGenetic Predisposition to DiseaseHumansIncidenceLogistic ModelsMaleMedical History TakingMiddle AgedMultivariate AnalysisNasopharyngeal Carcinomacase-control studyfamily historynasopharyngeal carcinoma (NPC)relative and cumulative risksouthern China

Identifiers

PMID28241094
PMCPMC5498222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.