ArticlePLoS pathogens2017
Nematode neuropeptides as transgenic nematicides.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Sclerotinia sclerotiorum growth and aggressiveness are regulated by a mycoviral REP protein.PLoS pathogens · 2025Article
- Host-induced RNA interference targeting the neuromotor gene FMRFamide-like peptide-14 (Mi-flp14) perturbs Meloidogyne incognita parasitic success in eggplant.Plant cell reports · 2024Article
- Unraveling the Roles of Neuropeptides in the Chemosensation of the Root-Knot NematodeInternational journal of molecular sciences · 2024Article
- StringentJournal of nematology · 2023Article
- Article
- Application Potential of Bacterial Volatile Organic Compounds in the Control of Root-Knot Nematodes.Molecules (Basel, Switzerland) · 2022Review
- Nematicidal Effects of Volatile Organic Compounds from Microorganisms and Plants on Plant-Parasitic Nematodes.Microorganisms · 2022Review
- In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes.International journal for parasitology · 2022Article
- Host-mediated RNAi for simultaneous silencing of different functional groups of genes in Meloidogyne incognita using fusion cassettes in Nicotiana tabacum.Plant cell reports · 2021Article
- Assessment and Validation ofCells · 2021Article
- FMRFamide-Like Peptide 22 Influences the Head Movement, Host Finding, and Infection ofFrontiers in plant science · 2021Article
- Simultaneous RNAi Knockdown of Three FMRFamide-Like Peptide Genes,Frontiers in microbiology · 2020Article
- A NovelFrontiers in plant science · 2020Article
- Host-Induced Silencing of FMRFamide-Like Peptide Genes,Frontiers in plant science · 2020Article
- ABC transporter genes ABC-C6 and ABC-G33 alter plant-microbe-parasite interactions in the rhizosphere.Scientific reports · 2019Article
- Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles.BMC genomics · 2019Article
- A Chemosensory GPCR as a Potential Target to Control the Root-Knot NematodeMolecules (Basel, Switzerland) · 2019Article
- The Nif3-Family Protein YqfO03 fromInternational journal of molecular sciences · 2018Article
- Plant-Parasitic Nematodes and Food Security in Sub-Saharan Africa.Annual review of phytopathology · 2018Review
- Volatile organic compounds from Paenibacillus polymyxa KM2501-1 control Meloidogyne incognita by multiple strategies.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a significant shortcoming in our ability to manage these economically important parasites, and highlights the need for novel and robust control methods. Nematodes can assimilate exogenous peptides through retrograde transport along the chemosensory amphid neurons. Peptides can accumulate within cells of the central nerve ring and can elicit physiological effects when released to interact with receptors on adjoining cells. We have profiled bioactive neuropeptides from the neuropeptide-like protein (NLP) family of PPNs as novel nematicides, and have identified numerous discrete NLPs that negatively impact chemosensation, host invasion and stylet thrusting of the root knot nematode Meloidogyne incognita and the potato cyst nematode Globodera pallida. Transgenic secretion of these peptides from the rhizobacterium, Bacillus subtilis, and the terrestrial microalgae Chlamydomonas reinhardtii reduce tomato infection levels by up to 90% when compared with controls. These data pave the way for the exploitation of nematode neuropeptides as a novel class of plant protective nematicide, using novel non-food transgenic delivery systems which could be deployed on farmer-preferred cultivars.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.