ArticlePLoS pathogens2017
OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Viral and host determinants of arboviral disease severity in African populations: A systematic review with meta-analysis.PLoS neglected tropical diseases · 2026Pooled it
- Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis.BMC infectious diseases · 2018Pooled it
- A decade of dengue disease burden in Africa (2013-2023): a systematic review.Travel medicine and infectious diseasePooled it
- Genomic epidemiology of dengue virus serotype 3 lineage 3III_B.3.2 in Brazil: insights into its spread and dengue severity amid co-circulation of multiple dengue serotypes.Lancet regional health. Americas · 2026Article
- Dengue and severe dengue.Clinical microbiology reviews · 2025Review
- Dengue virus and lipid metabolism: unravelling the interplay for future therapeutic approaches.Emerging microbes & infections · 2025Review
- Risk factors predicting dengue hospitalization and disease severity in children and adolescents living in an endemic area of arbovirus transmission in Northeast Brazil (2017-2020).BMC public health · 2025Article
- Potential prognostic biomarker of OSBPL10 in pan-cancer associated with immune infiltration.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions.Signal transduction and targeted therapy · 2025Review
- Genetic ancestry shapes dengue virus infection in human skin explants.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dissecting genomes of multiple yak populations: unveiling ancestry and high-altitude adaptation through whole-genome resequencing analysis.BMC genomics · 2025Article
- An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan.Scientific reports · 2025Article
- Identifying low-density, ancestry-informative SNP markers through whole genome resequencing in Indian, Chinese, and wild yak.BMC genomics · 2024Article
- Article
- The Dynamic Relationship between Dengue Virus and the Human Cutaneous Innate Immune Response.Viruses · 2024Review
- Flying under the radar - impact and factors influencing asymptomatic DENV infections.Frontiers in cellular and infection microbiology · 2023Review
- Immune system gene polymorphisms associated with severe dengue in Latin America: a systematic review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2023Article
- Adverse Drug Reactions during COVID-19 Treatment: A Comprehensive Analysis Focused on Hospitalized Patients, with the Use of a Survey in Cuba in 2020.Advances in pharmacological and pharmaceutical sciences · 2023Article
- Emergence and evolution of SARS-CoV-2 genetic variants during the Cuban epidemic.Journal of clinical virology plus · 2022Article
- Importance of Including Non-European Populations in Large Human Genetic Studies to Enhance Precision Medicine.Annual review of biomedical data science · 2022Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ethnic groups can display differential genetic susceptibility to infectious diseases. The arthropod-born viral dengue disease is one such disease, with empirical and limited genetic evidence showing that African ancestry may be protective against the haemorrhagic phenotype. Global ancestry analysis based on high-throughput genotyping in admixed populations can be used to test this hypothesis, while admixture mapping can map candidate protective genes. A Cuban dengue fever cohort was genotyped using a 2.5 million SNP chip. Global ancestry was ascertained through ADMIXTURE and used in a fine-matched corrected association study, while local ancestry was inferred by the RFMix algorithm. The expression of candidate genes was evaluated by RT-PCR in a Cuban dengue patient cohort and gene set enrichment analysis was performed in a Thai dengue transcriptome. OSBPL10 and RXRA candidate genes were identified, with most significant SNPs placed in inferred weak enhancers, promoters and lncRNAs. OSBPL10 had significantly lower expression in Africans than Europeans, while for RXRA several SNPs may differentially regulate its transcription between Africans and Europeans. Their expression was confirmed to change through dengue disease progression in Cuban patients and to vary with disease severity in a Thai transcriptome dataset. These genes interact in the LXR/RXR activation pathway that integrates lipid metabolism and immune functions, being a key player in dengue virus entrance into cells, its replication therein and in cytokine production. Knockdown of OSBPL10 expression in THP-1 cells by two shRNAs followed by DENV2 infection tests led to a significant reduction in DENV replication, being a direct functional proof that the lower OSBPL10 expression profile in Africans protects this ancestry against dengue disease.
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