Evidence map›Paper›PMID 28240744›Full record

ArticleScientific reports2017

Serum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody.

Qiang Jia, Zhaowei Meng, Ke Xu, Xianghui He, Jian Tan, Guizhi Zhang, Xue Li, Na Liu, Tianpeng Hu, Pingping Zhou and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
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  8. Review
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Qiang JiaDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Zhaowei MengDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Ke XuTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Micro-environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Xianghui HeDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Jian TanDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Guizhi ZhangDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Xue LiDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Na LiuDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Tianpeng HuDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Pingping ZhouDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Sen WangDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Arun UpadhyayaDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Xiaoxia LiuDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Huiying WangDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Chunmei ZhangDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, P.R. China.
Tianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of midkine (MK) as a cancer biomarker for DTC patients with positive TgAb before the first

Indexed as

Biomarkers, TumorAdultAutoantibodiesFemaleHumansIntercellular Signaling Peptides and ProteinsIodine RadioisotopesMaleMiddle AgedMidkineNeoplasm GradingNeoplasm MetastasisNeoplasm StagingPrognosisROC CurveThyroid Neoplasmsanti-thyroglobulinAutoantibodiesBiomarkers, TumorIntercellular Signaling Peptides and ProteinsIodine RadioisotopesMidkine

Identifiers

PMID28240744
PMCPMC5378906
OpenAlexW2592455157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.