Evidence map›Paper›PMID 28240554›Full record

ArticleJournal of the American Chemical Society2017

Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation.

Shu-Shan Gao, Marc Garcia-Borràs, Joyann S Barber, Yang Hai, Abing Duan, Neil K Garg, K N Houk, Yi Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shu-Shan GaoDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
Marc Garcia-BorràsDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
Joyann S BarberDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
Yang HaiDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.ORCID 0000-0002-2039-5367
Abing DuanDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
Neil K GargDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.ORCID 0000-0002-7793-2629
K N HoukDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.ORCID 0000-0002-8387-5261
Yi TangDepartment of Chemical and Biomolecular Engineering and ⊥Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.ORCID 0000-0003-1597-0141

Funding

CHEMISTRY BIOLOGY INTERFACE TRAINING PROGRAMT32GM008496 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYNARD, HEATHER D · 1993 to 2019
$6.3M
MIRA: Enzymology and Self-Resistance of Natural Product BiosynthesisR35GM118056 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yi Tang · 2016 to 2026
$6.1M
Rediscovering Natural Chemical Diversity -1DP1GM106413DP1GM106413 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TANG, YI · 2012 to 2016
$3.9M
NIGMS NIH HHS DP1 GM106413NIGMS NIH HHS R35 GM118056NIGMS NIH HHS T32 GM008496
6 · The paper itself

Abstract

Hydroalkoxylation is a powerful and efficient method of forming C-O bonds and cyclic ethers in synthetic chemistry. In studying the biosynthesis of the fungal natural product herqueinone, we identified an enzyme that can perform an intramolecular enantioselective hydroalkoxylation reaction. PhnH catalyzes the addition of a phenol to the terminal olefin of a reverse prenyl group to give a dihydrobenzofuran product. The enzyme accelerates the reaction by 3 × 10

Indexed as

BiocatalysisLyasesMolecular StructurePhenalenesQuantum TheoryStereoisomerismherquienoneLyasesPhenalenes

Identifiers

PMID28240554
PMCPMC5474393

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.