ArticleACS combinatorial science2017
Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction.
Article in ACS combinatorial science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Formaldehyde surrogates in multicomponent reactions.Beilstein journal of organic chemistry · 2025Review
- Article
- Isocyanide-Based Multicomponent Reactions in Water: Advanced Green Tools for the Synthesis of Heterocyclic Compounds.Topics in current chemistry (Cham) · 2022Review
- Synthesis of N-heterocycles containing 1,5-disubstituted-1H-tetrazole via post-Ugi-azide reaction.Molecular diversity · 2020Review
- One-Pot Parallel Synthesis of 5-(Dialkylamino)tetrazoles.ACS combinatorial science · 2019Article
- Tetrazoles via Multicomponent Reactions.Chemical reviews · 2019Review
- Combining the Ugi-azide multicomponent reaction and rhodium(III)-catalyzed annulation for the synthesis of tetrazole-isoquinolone/pyridone hybrids.Beilstein journal of organic chemistry · 2019Article
- Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides.Beilstein journal of organic chemistry · 2019Article
- Library-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction.ACS combinatorial science · 2018Review
- Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles.Beilstein journal of organic chemistry · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.