ArticleHuman brain mapping2017
Genetic and environmental influences on mean diffusivity and volume in subcortical brain regions.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Prenatal exposure to hypertensive disorders and adolescent brain white matter development.Pediatric research · 2026Article
- Neonatal amygdala and fear processing across early childhood.European child & adolescent psychiatry · 2026Article
- Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men.Alzheimer's research & therapy · 2024Article
- Genetic and Environmental Influences on Structural and Diffusion-Based Alzheimer's Disease Neuroimaging Signatures Across Midlife and Early Old Age.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Higher cortical thickness/volume in Alzheimer's-related regions: protective factor or risk factor?Neurobiology of aging · 2023Article
- Genetic and Environmental Contributions to Subcortical Gray Matter Microstructure and Volume in the Developing Brain.Behavior genetics · 2023Article
- The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years.Frontiers in aging neuroscience · 2022Article
- SLC25A24 gene methylation and gray matter volume in females with and without conduct disorder: an exploratory epigenetic neuroimaging study.Translational psychiatry · 2021Article
- 12-year prediction of mild cognitive impairment aided by Alzheimer's brain signatures at mean age 56.Brain communications · 2021Article
- Intact microstructure of the right corticostriatal pathway predicts creative ability in healthy adults.Brain and behavior · 2020Article
- Significant Decrease in Hippocampus and Amygdala Mean Diffusivity in Treatment-Resistant Depression Patients Who Respond to Electroconvulsive Therapy.Frontiers in psychiatry · 2019Article
- Beyond heritability: improving discoverability in imaging genetics.Human molecular genetics · 2018Review
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Authors and funding
11 authors.
Funding
Abstract
Increased mean diffusivity (MD) is hypothesized to reflect tissue degeneration and may provide subtle indicators of neuropathology as well as age-related brain changes in the absence of volumetric differences. Our aim was to determine the degree to which genetic and environmental variation in subcortical MD is distinct from variation in subcortical volume. Data were derived from a sample of 387 male twins (83 MZ twin pairs, 55 DZ twin pairs, and 111 incomplete twin pairs) who were MRI scanned as part of the Vietnam Era Twin Study of Aging. Quantitative estimates of MD and volume for 7 subcortical regions were obtained: thalamus, caudate nucleus, putamen, pallidum, hippocampus, amygdala, and nucleus accumbens. After adjusting for covariates, bivariate twin models were fitted to estimate the size and significance of phenotypic, genotypic, and environmental correlations between MD and volume at each subcortical region. With the exception of the amygdala, familial aggregation in MD was entirely explained by additive genetic factors across all subcortical regions with estimates ranging from 46 to 84%. Based on bivariate twin modeling, variation in subcortical MD appears to be both genetically and environmentally unrelated to individual differences in subcortical volume. Therefore, subcortical MD may be an alternative biomarker of brain morphology for complex traits worthy of future investigation. Hum Brain Mapp 38:2589-2598, 2017. © 2017 Wiley Periodicals, Inc.
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