Evidence map›Paper›PMID 28240381›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2017

The Global Network Neonatal Cause of Death algorithm for low-resource settings.

Ana L Garces, Elizabeth M McClure, Wilton Pérez, K Michael Hambidge, Nancy F Krebs, Lester Figueroa, Carl L Bose, Waldemar A Carlo, Constance Tenge, Fabian Esamai and 15 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438110 (Project to Understand & Research Preterm Pregnancy Outcomes-South Asia), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03438110 completednot on this mapstarted 2018, after this paper: background citation

Project to Understand & Research Preterm Pregnancy Outcomes-South Asia (PURPOSe)

TypeobservationalSponsorRTI InternationalRan2018 to 2020Enrolled1,226ConditionsNeonatal Death, Stillbirth
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Prevalence and presentation of neonatal sepsis at a paediatric emergency department in Johannesburg, South Africa.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2022
    Article
  6. Article
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  8. Observational
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  12. Congenital obstructive bowel anomalies presenting after neonatal age.Malawi medical journal : the journal of Medical Association of Malawi · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 17 institutions in 7 countries.

Ana L GarcesINCAP, Guatemala City, Guatemala.
Elizabeth M McClureRTI International, Durham, NC, USA.
Wilton PérezINCAP, Guatemala City, Guatemala.
K Michael HambidgeUniversity of Colorado, Denver, CO, USA.
Nancy F KrebsUniversity of Colorado, Denver, CO, USA.
Lester FigueroaINCAP, Guatemala City, Guatemala.
Carl L BoseUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Waldemar A CarloUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Constance TengeMoi University School of Medicine, Eldoret, Kenya.
Fabian EsamaiMoi University School of Medicine, Eldoret, Kenya.
Shivaprasad S GoudarKLE University's JN Medical College, Belgaum, India.
Sarah SaleemAga Khan University, Karachi, Pakistan.
Archana B PatelLata Medical Research Foundation, Nagpur, India.
Melody ChiwilaCIDRZ, Lusaka, Zambia.
Elwyn ChombaUniversity of Zambia, Lusaka, Zambia.
Antoinette TshefuKinshasa School of Public Health, Kinshasa, DRC.
Richard J DermanThomas Jefferson University, Philadelphia, PA, USA.
Patricia L HibberdBoston University, Boston, MA, USA.
Sherri BucherIndiana University, Indianapolis, IN, USA.
Edward A LiechtyIndiana University, Indianapolis, IN, USA.
Melissa BausermanUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Janet L MooreRTI International, Durham, NC, USA.
Marion Koso-ThomasNICHD, Bethesda, MD, USA.
Menachem MiodovnikNICHD, Bethesda, MD, USA.
Robert L GoldenbergColumbia University Medical Center, New York, NY, USA.
Institute of Nutrition of Central America and Panama · GTEunice Kennedy Shriver National Institute of Child Health and Human Development · USIndiana University IndianapolisMoi University · KERTI International · USUniversity of Colorado Denver · USUniversity of North Carolina at Chapel Hill · USAga Khan University · PKBoston University · USCentre for Infectious Disease Research in Zambia · ZMColumbia University Irving Medical Center · USKLE University · INLata Medical Research Foundation · INMinistry of Public Health · CDThomas Jefferson University · USUniversity of Alabama at Birmingham · USUniversity of Zambia · ZM

Funding

Zika in Pregnancy Supplemental Funding requestU01HD040636 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI MCCLURE, ELIZABETH M · 2001 to 2017
$37.5M
Global Network for Women's and Children's Health Research Data Coordinating CenterU24HD092094 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Elizabeth M McClure · 2017 to 2026
$17.8M
UAB/AKU Global Network Research UnitU01HD040607 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOLDENBERG, ROBERT L · 2001 to 2012
$8.5M
Complementary feeding: a Global Network cluster randomized controlled trialU01HD040657 · NICHD · UNIVERSITY OF COLORADO DENVER · PI HAMBIDGE, K MICHAEL · 2001 to 2012
$8.1M
UMKC-JNMC Global Network for Women's and Children's Health Research UnitU01HD042372 · NICHD · UNIVERSITY OF MISSOURI KANSAS CITY · PI DERMAN, RICHARD J · 2001 to 2012
$6.9M
Neonatal Resuscitation in Developing CountriesU01HD043464 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 2003 to 2012
$6.6M
Evidence-Based Global Health Interventions for Mothers and Children, ArgentinaU01HD040477 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BUEKENS, PIERRE · 2001 to 2013
$5.6M
Boston University/Lata Medical Research Foundation Global Network for Women's Children's Health Research UnitUG1HD078439 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Patricia L Hibberd · 2018 to 2026
$5.5M
TJU-JNMC Global Network for Women's & Children's Health Research UnitUG1HD076457 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI RICHARD J DERMAN · 2018 to 2026
$5.5M
Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
The Global Network and Preconception Maternal NutritionU10HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KREBS, NANCY F · 2013 to 2017
$5.1M
Improving Quality of Care for the Treatment of Childhood PneumoniaU01HD058322 · NICHD · TUFTS UNIVERSITY BOSTON · PI HIBBERD, PATRICIA L · 2008 to 2012
$4.0M
NICHD NIH HHS U01 HD040477NICHD NIH HHS U01 HD040607NICHD NIH HHS U01 HD040636NICHD NIH HHS U01 HD040657NICHD NIH HHS U01 HD042372NICHD NIH HHS U01 HD043464NICHD NIH HHS U01 HD058322NICHD NIH HHS U01 HD058326NICHD NIH HHS U10 HD076457NICHD NIH HHS U10 HD076465NICHD NIH HHS U10 HD076474NICHD NIH HHS U10 HD078438NICHD NIH HHS U10 HD078439NICHD NIH HHS U24 HD092094NICHD NIH HHS UG1 HD076457NICHD NIH HHS UG1 HD076474NICHD NIH HHS UG1 HD078439
6 · The paper itself

Abstract

aimThis study estimated the causes of neonatal death using an algorithm for low-resource areas, where 98% of the world's neonatal deaths occur.

methodsWe enrolled women in India, Pakistan, Guatemala, the Democratic Republic of Congo, Kenya and Zambia from 2014 to 2016 and tracked their delivery and newborn outcomes for up to 28 days. Antenatal care and delivery symptoms were collected using a structured questionnaire, clinical observation and/or a physical examination. The Global Network Cause of Death algorithm was used to assign the cause of neonatal death, analysed by country and day of death.

resultsOne-third (33.1%) of the 3068 neonatal deaths were due to suspected infection, 30.8% to prematurity, 21.2% to asphyxia, 9.5% to congenital anomalies and 5.4% did not have a cause of death assigned. Prematurity and asphyxia-related deaths were more common on the first day of life (46.7% and 52.9%, respectively), while most deaths due to infection occurred after the first day of life (86.9%). The distribution of causes was similar to global data reported by other major studies.

conclusionThe Global Network algorithm provided a reliable cause of neonatal death in low-resource settings and can be used to inform public health strategies to reduce mortality.

Indexed as

Cause of DeathDeveloping CountriesInfant MortalityAlgorithmsFemaleHumansInfantInfant, NewbornPregnancyGlobal Network Cause of Death algorithmInfectionLow- to middle-income countriesNeonatal mortalityPreterm birth

Identifiers

PMID28240381
PMCPMC5425300
OpenAlexW2593984057

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.