ArticleScientific reports2017
Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of β-thalassemia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Comparative Analysis of Ultrasonography and MicroCT Imaging for Organ Size Evaluation in Mice.Journal of imaging · 2025Article
- Thalassemia in Sub-Saharan Africa: epidemiology, diagnosis, and management - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Understanding erythroid physiology and pathology in humanized mice: A closer look.British journal of haematology · 2025Review
- Improved MRI detection of inflammation-induced changes in bone marrow microstructure in mice: a machine learning-enhanced T2 distribution analysis.European radiology experimental · 2025Article
- QuantitativeMagma (New York, N.Y.) · 2024Article
- Monitoring longitudinal disease progression in a novel murine Kit tumor model using high-field MRI.Scientific reports · 2022Article
- Survey of water proton longitudinal relaxation in liver in vivo.Magma (New York, N.Y.) · 2021Review
- Myocardial Viability Imaging using Manganese-Enhanced MRI in the First Hours after Myocardial Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Characterization of acute TLR-7 agonist-induced hemorrhagic myocarditis in mice by multiparametric quantitative cardiac magnetic resonance imaging.Disease models & mechanisms · 2019Article
- In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques.Scientific reports · 2019Article
- The application value of ultra-short echo time MRI in the quantification of liver iron overload in a rat model.Quantitative imaging in medicine and surgery · 2019Article
- Assessment of MR-based R2* and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T.Magnetic resonance in medicine · 2018Article
- Involvement of cytosolic and mitochondrial iron in iron overload cardiomyopathy: an update.Heart failure reviews · 2018Review
- Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism.The journal of physiological sciences : JPS · 2018Review
- Emerging Therapies.Hematology/oncology clinics of North America · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
β-thalassemia (βT) is a genetic blood disorder causing profound and life threatening anemia. Current clinical management of βT is a lifelong dependence on regular blood transfusions, a consequence of which is systemic iron overload leading to acute heart failure. Recent developments in gene and chelation therapy give hope of better prognosis for patients, but successful translation to clinical practice is hindered by the lack of thorough preclinical testing using representative animal models and clinically relevant quantitative biomarkers. Here we demonstrate a quantitative and non-invasive preclinical Magnetic Resonance Imaging (MRI) platform for the assessment of βT in the γβ
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.