Evidence map›Paper›PMID 28240301›Full record

ArticleScientific reports2017

Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.

Hui Wang, Lihua Mo, Xiaojun Xiao, Shu An, Xiaoyu Liu, Jinge Ba, Weifang Wu, Pixin Ran, Pingchang Yang, Zhigang Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hui WangState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Lihua MoState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Xiaojun XiaoState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Shu AnLuohu district people's hospital, Shenzhen, China.
Xiaoyu LiuState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Jinge BaState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Weifang WuState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Pixin RanState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510006, China.
Pingchang YangState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Zhigang LiuState Key Laboratory of Respiratory Disease for Allergy at Shenzhen University, Shenzhen Key Laboratory of Allergy &Immunology, Shenzhen University School of Medicine, Shenzhen, China.
Shenzhen University · CNLonggang Central Hospital · CNGuangzhou Medical University · CNShenzhen Luohu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous studies revealed that many proteins in addition to the known allergens of D. farinae have not been fully characterized. We observed that Pplase did not respond to serum collected from patients sensitized to D. farinae. In a mouse model, Pplase significantly enhanced airway hyperresponsiveness (AHR) and Th2 responses induced by ovalbumin (OVA) compared with mice treated with OVA alone. Moreover, exposure to Pplase significantly increased the expression of IRF4, CD80, CD83, MHCII and TNF-α in DC2.4 cells, which was abolished in the presence of a TLR4 inhibitor. In vitro T cell polarization experiments revealed that Pplase alone could not induce T cell polarization but enhanced T cell polarization together with OVA. In addition, transfer of Pplase-primed bone marrow-derived DCs (BMDCs) to naïve mice enhanced AHR and Th2 immune responses in mice sensitized to OVA. In conclusion, Pplase is not an allergen of D. farinae but can activate DC cells to facilitate OVA-induced allergic responses.

Indexed as

AdultAllergensAnimalsAntigens, CDArthropod ProteinsB7-1 AntigenBasic Helix-Loop-Helix ProteinsCD83 AntigenCell LineDendritic CellsDermatophagoides farinaeDisease Models, AnimalFemaleGene Expression RegulationHistocompatibility Antigens Class IIHumansAhr protein, mouseAllergensAntigens, CDArthropod ProteinsB7-1 AntigenBasic Helix-Loop-Helix ProteinsCD83 Antigenethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylateHistocompatibility Antigens Class IIImmunoglobulinsInterferon Regulatory Factor-4Interferon Regulatory FactorsMembrane GlycoproteinsOvalbuminPeptidylprolyl IsomeraseReceptors, Aryl HydrocarbonSulfonamidesTlr4 protein, mouseToll-Like Receptor 4Tumor Necrosis Factor-alpha

Identifiers

PMID28240301
PMCPMC5327411
OpenAlexW2593447521

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.