ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
The Role of Dorsal Hippocampal Dopamine D1-Type Receptors in Social Learning, Social Interactions, and Food Intake in Male and Female Mice.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 36 citations in OpenAlex.
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- A homecage operant paradigm reveals behavioral dynamics of social motivation in mice.Cell reports methods · 2026Article
- Hippocampus Oxytocin Signaling Promotes Prosocial Eating in Rats.Biological psychiatry · 2025Article
- Social Interaction in Adolescent Rats with Neonatal Ethanol Exposure: Impact of Sex and CE-123, a Selective Dopamine Reuptake Inhibitor.International journal of molecular sciences · 2024Article
- The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders.Brain sciences · 2021Review
- Dopaminergic signaling supports auditory social learning.Scientific reports · 2021Article
- Region-dependent regulation of acute ethanol on γ oscillation in the rat hippocampal slices.Psychopharmacology · 2020Article
- Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems.Brain structure & function · 2020Article
- Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled.Current biology : CB · 2019Article
- Hippocampus ghrelin receptor signaling promotes socially-mediated learned food preference.Neuropharmacology · 2018Article
- Sex differences in the brain: Implications for behavioral and biomedical research.Neuroscience and biobehavioral reviews · 2018Review
- Ventral midline thalamus is not necessary for systemic consolidation of a social memory in the rat.Brain and neuroscience advancesArticle
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The neurobiological mechanisms underlying social learning (ie, in which an animal's learning is influenced by another) are slowly being unraveled. Previous work with systemic treatments shows that dopamine (DA) D1-type receptors mediate social learning in the social transmission of food preferences (STFP) in mice. This study examines the involvement of one brain region underlying this effect. The ventral tegmental area has dopaminergic projections to many limbic structures, including the hippocampus-a site important for social learning in the STFP in rodents. In this study, adult male and female CD-1 mice received a dorsal hippocampal microinfusion of the D1-like receptor antagonist SCH23390 at 1, 2, 4, or 6 μg/μl 15 min before a 30 min social interaction with a same-sex conspecific, in which mice had the opportunity to learn a socially transmitted food preference. Results show that social learning was blocked in female mice microinfused with 6 μg/μl, and in males infused with 1, 4, or 6 μg/μl of SCH23390. This social learning impairment could not be explained by changes in total food intake, or olfactory discrimination. A detailed analysis of the social interactions also revealed that although SCH23390 did not affect oronasal investigation for either sex, drug treatments affected other social behaviors in a sex-specific manner; there was primarily a reduction in agonistic-related behaviors among males, and social investigatory-related behaviors among females. Thus, this study shows that dorsal hippocampal D1-type receptors mediate social learning and social behaviors in male and female mice.
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