ArticleNeurosurgical review2018
Primary acquired spondylodiscitis shows a more severe course than spondylodiscitis following spine surgery: a single-center retrospective study of 159 cases.
Article in Neurosurgical review, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Practical Application of the AO Spine Primary Infection Classification System: Clarifying Definitions, Borderline Cases and Common Misinterpretations.Global spine journal · 2026Review
- Publicly Accessible Large Language Model Responses to Frequently Asked Questions About Spondylodiscitis: Preliminary Expert Evaluation.Journal of medical Internet research · 2026Article
- The MSI-20 Score Provides Reproducible Mortality Risk Stratification in Spinal Infection: A Multicenter Registry Study and External Validation.Neurospine · 2026Article
- Infectious Spondylodiscitis of Bacterial Causes in Adults: Epidemiology, Pathophysiology, Diagnostic and Treatment Challenges.Microorganisms · 2026Review
- Clinical and radiological features of infectious spondylodiscitis in an Italian cohort: a retrospective study.Brain & spine · 2026Article
- Surgical outcomes of minimally invasive microscopic debridement in thoracolumbar pyogenic spondylodiscitis.Scientific reports · 2025Article
- Local antibiotic carriers in the surgical management of pyogenic spondylodiscitis : First comparative evaluation of gentamicin-loaded versus vancomycin-loaded efficacy.Orthopadie (Heidelberg, Germany) · 2025Article
- Global Insights Into Spondylodiscitis: A Bibliometric Analysis of Four Decades of Research.Cureus · 2025Review
- The Need for Comprehensive Medical Management in Pyogenic Spondylodiscitis: A Review Article.Spine surgery and related research · 2024Review
- Laboratory diagnostics for primary spinal infections in pediatric and adult populations: a narrative review.North American Spine Society journal · 2023Article
- An Assessment of the Safety of Surgery and Hardware Placement in de-novo Spinal Infections. A Systematic Review and Meta-Analysis of the Literature.Global spine journal · 2023Review
- Clinical phenotyping of spondylodiscitis and isolated spinal epidural empyema: a 20-year experience and cohort study.Frontiers in surgery · 2023Article
- Neurosurgical Management and Outcome Parameters in 237 Patients with Spondylodiscitis.Brain sciences · 2021Article
- Management of Pyogenic Spondylodiscitis Following Nonspinal Surgeries: A Tertiary Care Center Experience.International journal of spine surgery · 2021Article
- Gender-Specific Differences in Presentation and Management of Spinal Infection: A Single-Center Retrospective Study of 159 Cases.Global spine journal · 2021Article
- Early surgery may lower mortality in patients suffering from severe spinal infection.Acta neurochirurgica · 2020Article
- Management of spinal infection: a review of the literature.Acta neurochirurgica · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spondylodiscitis may arise primarily via hematogenous spread or direct inoculation of virulent organisms during spine surgery. To date, no comparative data investigating the differences between primary and postoperative spondylodiscitis is available. Thus, the purpose of this retrospective study was to investigate differences between these two etiologies. One hundred fifty-nine patients that were treated at our department were included in the retrospective analysis. The patients were categorized into two groups based on the etiology of spondylodiscitis: group NS, primary spondylodiscitis without prior spinal surgery; group S, spondylodiscitis following spinal surgery. Evaluation included magnetic resonance imaging (MRI), laboratory values, clinical outcome, and operative or conservative management. Preoperative MRI showed higher rates of epidural and paraspinal abscess in patients with primary spondylodiscitis (p < 0.005). Vertebral bone destruction was more severe in group NS (p < 0.05). Survival rate in group S (98.2%) was higher than in group NS (87.5%, p = 0.024). The extent of the operative procedure in patients who were surgically treated (n = 116) differed between the two groups (p < 0.005). In conclusion, spondylodiscitis is a life-threatening and serious disease and requires long-term treatment. Primary spondylodiscitis is frequently associated with epidural and paraspinal abscess, vertebral bone destruction and has a higher mortality rate than postoperative spondylodiscitis. Therefore, primary spondylodiscitis shows a more severe course than spondylodiscitis following spine surgery.
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