Evidence map›Paper›PMID 28239687›Full record

ArticleLupus (Los Angeles)2016

Protein Phosphatase 5 Contributes to the Overexpression of Epigenetically Regulated T-Lymphocyte Genes in Patients with Lupus.

D Patel, G Gorelik, B Richardson

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Lupus (Los Angeles), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

D PatelEli Lilly and Company, San Diego, CA, USA; Rheumatology Division, Department of Medicine, University of Michigan, Ann Arbor MI, USA.
G GorelikRheumatology Division, Department of Medicine, University of Michigan, Ann Arbor MI, USA.
B RichardsonRheumatology Division, Department of Medicine, University of Michigan, Ann Arbor MI, USA; Department of Medicine, Ann Arbor VA Medical Center, Ann Arbor MI, USA.
Ann Arbor VA Medical Center · USEli Lilly (United States) · USMichigan Medicine · US

Funding

KIR+CD11ahiCD4+ T cells in Systemic AutoimmunityU19AI110502 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RICHARDSON, BRUCE C. · 2014 to 2018
$2.6M
NIAID NIH HHS U19 AI110502
6 · The paper itself

Abstract

objectiveLupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by the exogenous stressors. Current evidence indicates that these environmental agents can trigger lupus flares by inhibiting the replication of DNA methylation patterns during mitosis in CD4

resultsPP5 was found to be overexpressed in CD4

conclusionThe results indicate that PP5 increases expression of methylation sensitive T cell genes, and may contribute to the aberrant gene expression in CD4

Indexed as

AtherosclerosisDNA methylationLupusOxidative stressProtein phosphatase 5SignalingT cells

Identifiers

PMID28239687
PMCPMC5323243
OpenAlexW2583206409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.