Evidence map›Paper›PMID 28239683›Full record

ArticleJournal of pharmaceutics and drug research2016

Non-Feminizing Estrogens Do Not Exhibit Antidepressant-like Activity.

Katalin Prokai-Tatrai, Vien Nguyen, Laszlo Prokai

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of pharmaceutics and drug research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Katalin Prokai-TatraiCenter for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Vien NguyenCenter for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Laszlo ProkaiCenter for Neuroscience Discovery, Institute for Healthy Aging, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
University of North Texas · US

Funding

Novel Treatment of Menopausal Hot Flushes with an Extradiol ProdrugR01AG031535 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI MERCHENTHALER, ISTVAN JOZSEF, PROKAI, LASZLO · 2009 to 2012
$2.2M
Novel molecular probes for membrane progesterone receptorsR21AG031421 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI PROKAI, KATALIN T · 2010 to 2011
$332k
NIA NIH HHS R01 AG031535NIA NIH HHS R21 AG031421
6 · The paper itself

Abstract

In this exploratory study, we performed an evaluation of non-feminizing estrogens as lead compounds for the safe treatment of menopausal symptoms. Despite confirming an enhancement of antioxidant potency as a consequence of increased lipophilicity of the prototype structures, our analyses have revealed serious shortcomings regarding pharmaceutically important properties and drug-likeness. In addition, our assessment in an animal model of estrogen deprivation has confirmed that genomic mechanisms are required for the alleviation of menopause-associated depression. Therefore, non-feminizing estrogens are not suitable to fulfill their implicated premise to address unmet needs to treat neurological and psychiatric conditions associated with estrogen deprivation of the brain.

Indexed as

AntidepressantDrug-likenessEstrogensNon-feminizingPorsolt swim test

Identifiers

PMID28239683
PMCPMC5321232
OpenAlexW2552291887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.