Evidence map›Paper›PMID 28239638›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2017

Brain amyloid in preclinical Alzheimer's disease is associated with increased driving risk.

Brian R Ott, Richard N Jones, Richard B Noto, Don C Yoo, Peter J Snyder, Justine N Bernier, David B Carr, Catherine M Roe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Review
  3. Slowed Driving Reaction Time in Preclinical Alzheimer's Disease.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025
    Article
  4. Article
  5. Adverse driving behaviors increase over time as a function of preclinical Alzheimer's disease biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Cognitive Decline and Older Driver Crash Risk.Journal of the American Geriatrics Society · 2018
    Article
  19. Driving cessation over a 24-year period: Dementia severity and cerebrospinal fluid biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brian R OttDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurology, Rhode Island Hospital, Providence, RI, USA.
Richard N JonesDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurology, Rhode Island Hospital, Providence, RI, USA; Department of Psychiatry and Human Behavior, Rhode Island Hospital, Providence, RI, USA.
Richard B NotoDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, USA; Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
Don C YooDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, USA; Department of Diagnostic Imaging, Rhode Island Hospital, Providence, RI, USA.
Peter J SnyderDepartment of Neurology, Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurology, Rhode Island Hospital, Providence, RI, USA.
Justine N BernierDepartment of Neurology, Rhode Island Hospital, Providence, RI, USA.
David B CarrDepartment of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine and Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Catherine M RoeDepartment of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine and Neurology, Washington University School of Medicine, St. Louis, MO, USA.

Funding

Secondary Analyses and Archive of Naturalistic Driving Data in Aging and DementiaR03AG046472 · NIA · RHODE ISLAND HOSPITAL · PI LUO, GANG, OTT, BRIAN R · 2014 to 2014
$192k
NIA NIH HHS R03 AG046472
6 · The paper itself

Abstract

introductionPostmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD).

methodsWe administered driving questionnaires to 104 older drivers (19 AD, 24 mild cognitive impairment, and 61 cognitive normal) who had a recent

resultsThe frequency of violations or accidents was curvilinear with respect to standardized uptake value ratios, peaking around a value of 1.1 (model DISCUSSION: We found that driving risk is strongly related to accumulating amyloid on positron emission tomography, and that this trend is evident in the preclinical stage of AD. Brain amyloid burden may in part explain the increased crash risk reported in older adults.

Indexed as

Alzheimer's diseaseAssessment of cognitive disordersBiomarkersCognitive agingDementiaDrivingMCI (mild cognitive impairment)

Identifiers

PMID28239638
PMCPMC5318288

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.