ArticleNeurobiology of stress2017
Early adverse life events are associated with altered brain network architecture in a sex- dependent manner.
Article in Neurobiology of stress, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Neurobehavioural links from infant screen time to anxiety.EBioMedicine · 2026Article
- Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.Biology of sex differences · 2025Article
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation.Translational psychiatry · 2025Article
- Exploring the impact of biological sex on intrinsic connectivity networks in PTSD: A data-driven approach.Progress in neuro-psychopharmacology & biological psychiatry · 2025Article
- Functional brain network organization and multidomain resilience to neighborhood disadvantage in youth.The American psychologist · 2024Article
- Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI.Scientific reports · 2024Article
- Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work?The Journal of urology · 2024Review
- Neural correlates of perceived and relative resilience in male and female patients with irritable bowel syndrome.Neurogastroenterology and motility · 2024Article
- Early life stress and body-mass-index modulate brain connectivity in alcohol use disorder.Translational psychiatry · 2024Article
- Early life adversities and lifelong health outcomes: A review of the literature on large, social, long-lived nonhuman mammals.Neuroscience and biobehavioral reviews · 2023Review
- Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures.Scientific reports · 2023Article
- Racism as a Source of Pain.Journal of general internal medicine · 2023Review
- Connecting dots in disorders of gut-brain interaction: the interplay of stress and sex hormones in shaping visceral pain.Frontiers in psychiatry · 2023Review
- Early adverse life events and post-traumatic stress disorder in patients with constipation and suspected disordered defecation.Neurogastroenterology and motility · 2022Article
- Sense of Coherence Mediates the Relationship Between Cognitive Reserve and Cognition in Middle-Aged Adults.Frontiers in psychology · 2022Article
- The Role of Resilience in Irritable Bowel Syndrome, Other Chronic Gastrointestinal Conditions, and the General Population.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021Article
- Dysregulation in Sphingolipid Signaling Pathways is Associated With Symptoms and Functional Connectivity of Pain Processing Brain Regions in Provoked Vestibulodynia.The journal of pain · 2021Observational
- Early life adversity predicts brain-gut alterations associated with increased stress and mood.Neurobiology of stress · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionEarly adverse life events (EALs) increase the risk for chronic medical and psychiatric disorders by altering early neurodevelopment. The aim of this study was to examine associations between EALs and network properties of core brain regions in the emotion regulation and salience networks, and to test the influence of sex on these associations.
methodsResting-state functional and diffusion tensor magnetic resonance imaging were obtained in healthy individuals (61 men, 63 women). Functional and anatomical network properties of centrality and segregation were calculated for the core regions of the two networks using graph theory. Moderator analyses were applied to test hypotheses.
resultsThe type of adversity experienced influences brain wiring differently, as higher
conclusionsEmotion regulation and salience regions are susceptible to topological brain restructuring associated with EALs. The male and female brains appear to be differently affected by specific types of EALs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.