Evidence map›Paper›PMID 28239629›Full record

ArticleGSTF journal of advances in medical research2014

Troponin Mutation Caused Diastolic Dysfunction and Experimental Treatment in Transgenic Mice with Cardiomyopathy.

Yang Xu, Jie Tian, Xupei Huang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GSTF journal of advances in medical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yang Xupediatrics research institute in Children's hospital, Chongqing Medical University, Chongqing, China.
Jie TianChildren's Hospital, Chongqing Medical University, Chongqing, China.
Xupei HuangChildren's Hospital, Chongqing Medical University, Chongqing, China.
Children's Hospital of Chongqing Medical University · CNChongqing Medical University · CN

Funding

MBRS Support of Continuous Research Excellence at FAUS06GM073621 · NIGMS · FLORIDA ATLANTIC UNIVERSITY · PI NARAYANAN, RAMASWAMY · 2005 to 2008
$3.4M
Restrictive Cardiomyopathy Caused by Cardiac Troponin MutationsR15HL112130 · NHLBI · FLORIDA ATLANTIC UNIVERSITY · PI HUANG, XUPEI · 2012 to 2012
$434k
NHLBI NIH HHS R15 HL112130NIGMS NIH HHS S06 GM073621
6 · The paper itself

Abstract

Troponin, a contractile protein of the thin filament of striated muscle, consists of three subunits: troponin C (TnC), troponin T (TnT), and troponin I (TnI). Cardiac troponin I (cTnI) plays a critical role in regulation of cardiac function. The physiological effect of cTnI, as an inhibitory subunit of troponin complex, is to prevent the interaction between myosin heavy chain heads and actins, i.e. the cross-bridge formation, and to ensure a proper relaxation of cardiac myofilaments. In pathological conditions, the deficiency of cTnI or mutations in cTnI especially in the C-terminus of cTnI is associated with diastolic dysfunction caused by myofibril hypersensitivity to Ca

Indexed as

cardiomyopathygene mutationheart failuremyofilamenttransgenic mice

Identifiers

PMID28239629
PMCPMC5302009
OpenAlexW2066536990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.