Evidence map›Paper›PMID 28239568›Full record

ArticleWorld journal of virology2017

Expression of hepatitis B virus surface antigens induces defective gonad phenotypes in Caenorhabditis elegans.

Yi-Yin Chen, Li-Wei Lee, Wei-Ning Hong, Szecheng J Lo

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Yi-Yin ChenYi-Yin Chen, Li-Wei Lee, Szecheng J Lo, Department of Biomedical Science, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan.
Li-Wei LeeYi-Yin Chen, Li-Wei Lee, Szecheng J Lo, Department of Biomedical Science, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan.
Wei-Ning HongYi-Yin Chen, Li-Wei Lee, Szecheng J Lo, Department of Biomedical Science, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan.
Szecheng J LoYi-Yin Chen, Li-Wei Lee, Szecheng J Lo, Department of Biomedical Science, College of Medicine, Chang Gung University, Tao Yuan 333, Taiwan.
Chang Gung Memorial Hospital · TWChang Gung University · TWCreative Research Enterprises (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo test whether a simple animal,

methodsThree plasmids that were able to express the large, middle and small forms of HBsAgs (LHBsAg, MHBsAg, and SHBsAg, respectively) driven by a ubiquitous promoter (

resultsSevere defects in egg-laying, decreases in brood size, and gonad retardation were observed in transgenic worms expressing SHBsAg whereas moderate defects were observed in transgenic worms expressing LHBsAg and MHBsAg. RT-PCR analysis revealed that

conclusionEctopic expression of three forms of HBsAg that causes recognizable phenotypes in transgenic worms suggests that

Indexed as

Caenorhabditis elegansEndoplasmic reticulum stressGonad retardationGreen fluorescence proteinsHepatitis B virusSurface antigens

Identifiers

PMID28239568
PMCPMC5303856
OpenAlexW2587745246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.