Evidence map›Paper›PMID 28239534›Full record

ArticleEnvironmental sciences Europe2017

Transcriptome and metabolome analysis of liver and kidneys of rats chronically fed NK603 Roundup-tolerant genetically modified maize.

Robin Mesnage, Matthew Arno, Gilles-Eric Séralini, Michael N Antoniou

Abstract read
In one paragraph

Article in Environmental sciences Europe, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Dietary Behavior ofJournal of xenobiotics · 2021
    Article
  2. RoundupToxics · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robin MesnageDepartment of Medical and Molecular Genetics, Gene Expression and Therapy Group, Faculty of Life Sciences & Medicine, King's College London, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT UK.ORCID 0000-0003-1732-4741
Matthew ArnoGenomics Centre, King's College London, Waterloo Campus, 150 Stamford Street, London, SE1 9NH UK.
Gilles-Eric SéraliniInstitute of Biology, EA 2608 and Risk Pole, MRSH-CNRS, University of Caen, Esplanade de la Paix, 14032 Caen Cedex, France.
Michael N AntoniouDepartment of Medical and Molecular Genetics, Gene Expression and Therapy Group, Faculty of Life Sciences & Medicine, King's College London, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London, SE1 9RT UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA previous 2-year rat feeding trial assessing potential toxicity of NK603 Roundup-tolerant genetically modified maize revealed blood and urine biochemical changes indicative of liver and kidney pathology. In an effort to obtain deeper insight into these findings, molecular profiling of the liver and kidneys from the same animals was undertaken.

resultsTranscriptomics showed no segregation of NK603 maize and control feed groups with false discovery rates ranging from 43 to 83% at a cut-off

conclusionsEven if the biological relevance of the statistical differences presented in this study is unclear, our results are made available for scrutiny by the scientific community and for comparison in future studies investigating potential toxicological properties of the NK603 corn.

Indexed as

GlyphosateGMOMetabolomeRoundupToxicityTranscriptome

Identifiers

PMID28239534
PMCPMC5306156

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.