ArticleBrain and behavior2017
Uric acid is associated with vascular dementia in Chinese population.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Uric acid levels and their association with vascular dementia and Parkinson's disease dementia: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Pooled it
- Serum Uric Acid and the Risk of Dementia: A Systematic Review and Meta-Analysis.Frontiers in aging neuroscience · 2021Pooled it
- The Relationship between Serum Amyloid A Level and Cognitive Dysfunction in Patients with Vascular Dementia: Preliminary Findings.BioMed research international · 2021Trial
- Brain functional alterations associated with visuospatial working memory impairment in gouty arthritis patients.Quantitative imaging in medicine and surgery · 2025Article
- The uric acid-to-HDL ratio as a predictive biomarker for depression risk in adult women.Frontiers in psychiatry · 2025Article
- Elevated serum uric acid is associated with cognitive impairment in acute minor ischemic stroke patients.Heliyon · 2023Article
- Cognitive Status and Nutritional Markers in a Sample of Institutionalized Elderly People.Frontiers in aging neuroscience · 2022Article
- Traditional Chinese medicine promotes the control and treatment of dementia.Frontiers in pharmacology · 2022Review
- Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study.Neuropsychiatric disease and treatment · 2021Article
- The Influence of Serum Uric Acid Level on Alzheimer's Disease: A Narrative Review.BioMed research international · 2021Review
- Serum Irisin as a Potential Biomarker for Cognitive Decline in Vascular Dementia.Frontiers in neurology · 2021Article
- The Prognostic Value of Serum Uric Acid in Hospitalized Patients with Acute Cerebral Infarction.Disease markers · 2021Article
- High Blood Uric Acid Is Associated With Reduced Risks of Mild Cognitive Impairment Among Older Adults in China: A 9-Year Prospective Cohort Study.Frontiers in aging neuroscience · 2021Article
- Association between serum NPTX2 and cognitive function in patients with vascular dementia.Brain and behavior · 2020Article
- Uric acid is associated with cognitive impairment in the elderly patients receiving maintenance hemodialysis-A two-center study.Brain and behavior · 2020Article
- Elevated Levels of Serum Neurofilament Light Chain Associated with Cognitive Impairment in Vascular Dementia.Disease markers · 2020Article
- Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia.Disease markers · 2020Article
- TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia.Neural plasticity · 2020Article
- Increased Levels of Serum Neuregulin 1 Associated with Cognitive Impairment in Vascular Dementia.BioMed research international · 2020Article
- Uric acid is associated with vascular dementia in Chinese population.Brain and behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD. MATERIALS AND
methodsThere were altogether 127 VD subjects and 81 nondemented controls enrolled in our study. Serum UA, demographic, and clinical characteristics were recorded at baseline, and all participants underwent Mini-Mental State Examination (MMSE) at the beginning of the trial.
resultsThe VD group showed lower MMSE scores and serum UA levels than nondemented controls and there was significant statistical difference between the two groups (
conclusionsVD subjects have dramatically lower serum UA levels in comparison to nondemented controls. Lower serum UA levels are linked to cognitive dysfunction and could serve as a potential predictor for VD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.