ArticleBrain and behavior2017
Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.Neuropsychology review · 2023Pooled it
- Role of White Matter Microstructure in Impulsive Behavior.The Journal of neuropsychiatry and clinical neurosciences · 2022Pooled it
- Microbes on the Mind: Multi-modal Neuroimaging Reveals Gut-Brain Axes in Infants.bioRxiv : the preprint server for biology · 2026Article
- Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers.The Clinical neuropsychologist · 2025Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI.Scientific data · 2025Article
- Harmonization of diffusion MRI on healthy subjects using NeuroCombat and LongCombat: a B-Q MINDED brain intra- and inter-scanner study.Frontiers in neuroscience · 2025Article
- Accelerating Heritability, Genetic Correlation, and Genome-Wide Association Imaging Genetic Analyses in Complex Pedigrees.Human brain mapping · 2024Article
- A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms.Human brain mapping · 2024Article
- High-frequency longitudinal white matter diffusion- and myelin-based MRI database: Reliability and variability.Human brain mapping · 2023Article
- In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis.Molecular psychiatry · 2023Article
- Validation of cross-sectional and longitudinal ComBat harmonization methods for magnetic resonance imaging data on a travelling subject cohort.Neuroimage. Reports · 2022Article
- Exploring the course of adolescent anxiety and depression: associations with white matter tract microstructure.European archives of psychiatry and clinical neuroscience · 2022Article
- The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain-behavior relationships after stroke.Human brain mapping · 2022Review
- ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.Human brain mapping · 2022Article
- White matter in prolonged glucocorticoid response to psychological stress in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis.Brain : a journal of neurology · 2021Review
- Common genetic variation influencing human white matter microstructure.Science (New York, N.Y.) · 2021Article
- White matter microstructure and its relation to clinical features of obsessive-compulsive disorder: findings from the ENIGMA OCD Working Group.Translational psychiatry · 2021Article
- Registration quality filtering improves robustness of voxel-wise analyses to the choice of brain template.NeuroImage · 2021Article
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13 authors.
Funding
Abstract
backgroundIn preparation for longitudinal analyses of white matter development in youths with family histories of substance use disorders (FH+) or without such histories (FH-), we examined the reproducibility and reliability of global and regional measures of fractional anisotropy (FA) values, measured using the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA)-diffusion tensor imaging (DTI) protocol. Highly reliable measures are necessary to detect any subtle differences in brain development.
methodsFirst, we analyzed reproducibility data in a sample of 12 healthy young adults (ages 20-28) imaged three times within a week. Next, we calculated the same metrics in data collected 1-year apart in the sample of 68 FH+ and 21 FH- adolescents. This is a timeframe where within subject changes in white matter microstructure are small compared to between subject variance. Reproducibility was estimated by examining mean coefficients of variation (MCV), mean absolute differences (MAD), and intraclass correlations (ICC) for global and tract-specific FA values.
resultsWe found excellent reproducibility for whole-brain DTI-FA values and most of the white matter tracts, except for the corticospinal tract and the fornix in both adults and youths. There was no significant effect of FH-group on reproducibility (
conclusionOverall, this study demonstrated an excellent reproducibility of ENIGMA-DTI FA, positing it as viable analysis tools for longitudinal studies and other protocols that repeatedly assess white matter microstructure.
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