ArticleBrain and behavior2017
Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing-remitting MS.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Retinal Optical Coherence Tomography Longitudinal Measures as Prognostic Biomarkers in Multiple Sclerosis: Systematic Review and Meta-Analysis.Neurology(R) neuroimmunology & neuroinflammation · 2025Pooled it
- Optical coherence tomography (OCT) measurements and cognitive performance in multiple sclerosis: a systematic review and meta-analysis.Journal of neurology · 2023Pooled it
- Association of retinal layer thickness with brain volume and cortical thickness in older adults.Scientific reports · 2025Article
- Visual quality of life in NMOSD and MOGAD: profiles, dynamics and associations with ageing and vision.Journal of neurology · 2024Article
- Assessing the visual afferent pathway with the multifocal visual evoked potentials in the radiologically isolated syndrome.Scientific reports · 2024Observational
- Clinical and biological correlates of optical coherence tomography findings in schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis.Journal of neurology · 2023Article
- The Usefulness of Optical Coherence Tomography in Disease Progression Monitoring in Younger Patients with Relapsing-Remitting Multiple Sclerosis: A Single-Centre Study.Journal of clinical medicine · 2022Article
- Association of Retinal Layer Thickness With Cognition in Patients With Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Cognitive Decline in Multiple Sclerosis Is Related to the Progression of Retinal Atrophy and Presence of Oligoclonal Bands: A 5-Year Follow-Up Study.Frontiers in neurology · 2021Article
- Visual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research.Neuro-ophthalmology (Aeolus Press) · 2020Review
- Reduced retinal nerve fiber layer (RNFL) thickness in ALS patients: a window to disease progression.Journal of neurology · 2018Article
- Visual Pathway Measures are Associated with Neuropsychological Function in Multiple Sclerosis.Current eye research · 2018Article
- Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing-remitting MS.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNeurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated.
objectiveTo investigate the association between focal cortical volume and thickness of retinal layers.
methodsFifty-four patients (relapsing-remitting MS, mean age 40.5 years, mean disease duration 7.6 years, median EDSS 2) underwent OCT and MRI. The association between focal cortical volume and OCT measurements was investigated with voxel-based morphometry (VBM). Patterns of association were determined with Yeo's functional network atlas and the Harvard-Oxford cortical atlas. We used GEE models with cortical volumes from the FreeSurfer parcellation to confirm VBM results. Post hoc, we analyzed the association between OCT, focal cortical volumes, and an extended neuropsychological assessment in a subgroup of 14 patients.
resultsMacular retinal nerve fiber layer (mRNFL) and ganglion cell /inner plexiform layer (GCIPL) showed a robust association with mainly the insular cortex and the cingulate cortex. VBM findings were confirmed with FreeSurfer volumes. The post hoc analysis detected significant correlations between both OCT outcomes and cognition.
conclusionBesides the primary visual system, OCT outcomes show a correlation pattern with cortical regions that are known to be important for cognitive performance, predominantly the insula in both hemispheres. Thus, OCT should be further investigated as a marker for neurodegeneration in MS.
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