ArticleBrain and behavior2017
Association of vitamin D status and clinical and radiological outcomes in a treated MS population in Poland.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Factors associated with relapses in relapsing-remitting multiple sclerosis: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Association between vitamin D deficiency and multiple sclerosis- MRI significance: A scoping review.Heliyon · 2023Article
- Is there a window of opportunity for the therapeutic use of vitamin D in multiple sclerosis?Neural regeneration research · 2022Review
- Multiple sclerosis incidence rate in southern Iran: a Bayesian epidemiological study.BMC neurology · 2021Article
- Vitamin D and Selenium in a Thyroid Eye Disease Population in Texas.Neuro-ophthalmology (Aeolus Press) · 2019Article
- Article
- Sun Exposure across the Life Course Significantly Modulates Early Multiple Sclerosis Clinical Course.Frontiers in neurology · 2018Article
- Association of vitamin D status and clinical and radiological outcomes in a treated MS population in Poland.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D influences the immune system significantly. Previous studies have found that vitamin D deficiency in adolescence can play a significant role in increasing the risk of developing autoimmune diseases including multiple sclerosis. The aim of this study was to investigate the relationship between the vitamin D status in serum and clinical and radiological outcomes in a treated population in Poland.
methodsInclusion criteria met 83 adult patients aged 20-61 years with diagnosis of relapsing-remitting multiple sclerosis, who underwent immunomodulatory treatment which lasted at least 12 months. Levels of serum 25-hydroxyvitamin D were determined using radio-immuno assay. Magnetic resonance imaging of the brain and cervical part of a spinal cord was performed each time after 12 months of the treatment. Patients were assessed neurologically after 12 months of treatment, the level of disability was also assessed using Extended Disability Status Scale.
resultsThe largest group (63.8%) showed significant vitamin D deficiency (<20 ng/ml), 21.7% showed the suboptimal level of vitamin D (20-30 ng/ml). The normal level of 25(OH)D (>30 ng/ml) was observed in 14.5% of the patients. Statistically significant correlation was observed between the vitamin D status and frequency of relapses.
conclusionsOur findings confirm that deficiency of vitamin D in patients with MS is correlated with clinical and radiological course of the disease.
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Registered trials
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