ArticleBrain and behavior2017
Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence.
Article in Brain and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Psychosocial factors and hippocampal subfields: The Medea-7T study.Human brain mapping · 2023Pooled it
- Neural correlates of resilience to trauma during adolescence: A multi-modal study.JCPP advances · 2026Article
- Gray matter correlates of childhood maltreatment lack replicability in a multi-cohort brain-wide association study.Nature communications · 2025Article
- Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Neglect and Neurodevelopment: A Narrative Review Understanding the Link Between Child Neglect and Executive Function Deficits.Biomedicines · 2025Review
- The association between childhood adversity and hippocampal volumes is moderated by romantic relationship experiences.The European journal of neuroscience · 2025Article
- Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Association between Childhood Maltreatment and Depressive and Anxiety Symptoms among Men Who Have Sex with Men in Los Angeles.Journal of urban health : bulletin of the New York Academy of Medicine · 2023Article
- Positive or negative environmental modulations on human brain development: the morpho-functional outcomes of music training or stress.Frontiers in neuroscience · 2023Review
- The effects of sexual abuse on female adolescent brain structures.Scandinavian journal of child and adolescent psychiatry and psychology · 2023Article
- Sex-dependent risk factors for PTSD: a prospective structural MRI study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Disparities by Gender and Race/Ethnicity in Child Maltreatment and Memory Performance.Journal of interpersonal violence · 2022Article
- Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies.Translational psychiatry · 2021Review
- Association of gray matter volumes with general and specific dimensions of psychopathology in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- An ecological approach to understanding the developing brain: Examples linking poverty, parenting, neighborhoods, and the brain.The American psychologist · 2020Article
- Hippocampal and parahippocampal volumes vary by sex and traumatic life events in childrenJournal of psychiatry & neuroscience : JPN · 2020Article
- Changes in neuroplasticity following early-life social adversities: the possible role of brain-derived neurotrophic factor.Pediatric research · 2019Review
- Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence.Brain and behavior · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocampus. However, the hippocampus is a functionally and structurally heterogeneous region, and little is known about how maltreatment might affect hippocampal subregion development throughout important periods of plasticity. This study investigated whether childhood maltreatment was associated with the development of hippocampal subregion volumes from early to late adolescence. It also investigated associations between onset of psychiatric disorder and hippocampal subregion volume development.
methodsOne hundred and sixty-six (85 male) adolescents took part in three magnetic resonance imaging assessments during adolescence (mean age at each assessment: 12.79 [
resultsChildhood maltreatment was associated with the development of right total and left cornu ammonis 4 (CA4-DG) volumes from early to late adolescence. Early and late onset psychopathology was associated with the development of right presubiculum and right cornu ammonis 1 (CA1) volumes, respectively. Maltreatment findings appeared to be specific to males, whereas psychopathology findings appeared to be specific to females.
conclusionsThese findings provide evidence for possible deleterious effects of childhood maltreatment and early onset psychiatric disorder on the development of different subregions of the hippocampus. Altered development of the right CA1, on the other hand, might precede the development of late-adolescent onset psychopathology. Our results highlight the importance of considering development in research examining associations between stress, mental illness, and hippocampal morphology.
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