ArticleJournal of anesthesia & clinical research2017
Lidocaine Infusion: A Promising Therapeutic Approach for Chronic Pain.
Article in Journal of anesthesia & clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intravenous Lignocaine as an Analgesic Adjunct in Adolescent Idiopathic Scoliosis Surgery (IGNITE-AIS Study)
Effectiveness of Adjuvant Continuous Lidocaine in General Anesthesia on Depth of Anesthesia (qCON), Pain Response (qNOX), and Blood Sugar Levels in Elective Primary Tumor Craniotomy Surgery
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain: a Randomized, Double-Blinded, Placebo-Controlled, Cross-Over Trial.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Intra-Venous Lidocaine to Relieve Neuropathic Pain: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2019Pooled it
- The effect of continuous intravenous lidocaine infusion on postoperative analgesia in elderly patients undergoing laparoscopic colorectal surgery.BMC anesthesiology · 2025Trial
- Intravenous lidocaine vs. NSAIDs for migraine attack in the ED: a prospective, randomized, double-blind study.European journal of clinical pharmacology · 2022Trial
- Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery.Medicine · 2018Trial
- Targeting druggable kinases in neuropathic pain.npj drug discovery · 2026Review
- Dramatic Response to Lidocaine Infusion Therapy for Chronic Generalized Pain Secondary to Multiple Large Keloids.Cureus · 2025Article
- Review
- Systemic Lidocaine Infusion for Acute Pain Management in a Surgical Intensive Care Unit: A Single-Arm Pilot Trial.Journal of clinical medicine · 2025Article
- Effectiveness of intravenous lidocaine in treatment of burn pain: a systematic review and meta-analysis of randomzed controlled trials.Annals of medicine and surgery (2012) · 2025Article
- Innovative Management of Opioid-Induced Hyperalgesia Using Lidocaine Infusion: A Case Report.Cureus · 2024Article
- Analgesic drug use in patients with STEMI: Current perspectives and challenges.Frontiers in medicine · 2023Review
- Computational design of peptides to target NaeLife · 2022Article
- Lidocaine infusions in chronic pain management: A prospective case series analysis.British journal of pain · 2022Article
- Perioperative Dexmedetomidine or Lidocaine Infusion for the Prevention of Chronic Postoperative and Neuropathic Pain After Gynecological Surgery: A Randomized, Placebo-Controlled, Double-Blind Study.Pain and therapy · 2022Article
- Development of Eugenol-Embedded Calcium Citrate Nanoparticles as a Local Anesthetic Agent.ACS omega · 2021Article
- Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment.Cancers · 2021Review
- Role of Intravenous Lidocaine Infusion in the Treatment of Peripheral Neuropathy.Orthopedic reviews · 2021Review
- Optimizing Perioperative Use of Opioids: A Multimodal Approach.Current anesthesiology reports · 2020Article
- Utilization of Intravenous Lidocaine Infusion for the Treatment of Refractory Chronic Pain.Anesthesiology and pain medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Opioid abuse is a national epidemic in the United States, where it is estimated that a prescription drug overdose death occurs every 19 minutes. While opioids are highly effective in acute and subacute pain control, their use for treatment of chronic pain is controversial. Chronic opioids use is associated with tolerance, dependency, hyperalgesia. Although there are new strategies and practice guidelines to reduce opioid dependence and opioid prescription drug overdose, there has been little focus on development of opioid-sparing therapeutic approaches. Lidocaine infusion has been shown to be successful in controlling pain where other agents have failed. The opioid sparing properties of lidocaine infusion added to its analgesic and antihyperalgesic properties make lidocaine infusion a viable option for pain control in opioid dependent patients. In this review, we provide an overview of the opioid abuse epidemic, and we outline current evidence supporting the potential use of lidocaine infusion as an adjuvant therapeutic approach for management of chronic pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.