ArticleOxidative medicine and cellular longevity2017
Gut Microbiota in a Rat Oral Sensitization Model: Effect of a Cocoa-Enriched Diet.
Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- A systematic review: polyphenol's effect on food allergy via microbiome modulation.Frontiers in microbiology · 2025Pooled it
- Cocoa Supplementation Alleviates Gliadin-Induced Intestinal Dysbiosis in a Mouse Model of Celiac Disease.Foods (Basel, Switzerland) · 2026Article
- Modulation of Gut Microbiota by Cacao: Insights from an In Vitro Model.Current issues in molecular biology · 2025Article
- Dietary Polyphenols-Natural Bioactive Compounds with Potential for Preventing and Treating Some Allergic Conditions.Nutrients · 2023Review
- Research Progress on the Correlation between the Intestinal Microbiota and Food Allergy.Foods (Basel, Switzerland) · 2022Review
- Article
- Benefits of Polyphenols and Methylxanthines from Cocoa Beans on Dietary Metabolic Disorders.Foods (Basel, Switzerland) · 2021Review
- Rat Milk and Plasma Immunological Profile throughout Lactation.Nutrients · 2021Article
- Understanding the Gastrointestinal Protective Effects of Polyphenols using Foodomics-Based Approaches.Frontiers in immunology · 2021Review
- Cocoa Polyphenols and Gut Microbiota Interplay: Bioavailability, Prebiotic Effect, and Impact on Human Health.Nutrients · 2020Review
- Article
- The gut microbiota, environmental factors, and links to the development of food allergy.Clinical and molecular allergy : CMA · 2020Review
- Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats.Nutrients · 2019Article
- Cocoa Diet and Antibody Immune Response in Preclinical Studies.Frontiers in nutrition · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence is emerging suggesting a relation between dietary compounds, microbiota, and the susceptibility to allergic diseases, particularly food allergy. Cocoa, a source of antioxidant polyphenols, has shown effects on gut microbiota and the ability to promote tolerance in an oral sensitization model. Taking these facts into consideration, the aim of the present study was to establish the influence of an oral sensitization model, both alone and together with a cocoa-enriched diet, on gut microbiota. Lewis rats were orally sensitized and fed with either a standard or 10% cocoa diet. Faecal microbiota was analysed through metagenomics study. Intestinal IgA concentration was also determined. Oral sensitization produced few changes in intestinal microbiota, but in those rats fed a cocoa diet significant modifications appeared. Decreased bacteria from the Firmicutes and Proteobacteria phyla and a higher percentage of bacteria belonging to the Tenericutes and Cyanobacteria phyla were observed. In conclusion, a cocoa diet is able to modify the microbiota bacterial pattern in orally sensitized animals. As cocoa inhibits the synthesis of specific antibodies and also intestinal IgA, those changes in microbiota pattern, particularly those of the Proteobacteria phylum, might be partially responsible for the tolerogenic effect of cocoa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.