ArticlePolymer chemistry2016
Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems.
Article in Polymer chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Hydrophobic Monomer Incorporation Tunes the pH Responsivity of Polycationic Brushes.ACS macro letters · 2026Article
- pH-Responsive Materials for Therapy and Precision Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- Interaction of a porphyrinic cage with ethionamide: a spectroscopic and computational study.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Article
- Entropy-Driven Cellulosic Elastomer Self-Assembly for Mechanical Energy Harvesting and Self-Powered Sensing.Nano-micro letters · 2026Review
- Supramolecular self-assembly in Traditional Chinese Medicine: molecular mechanisms, material basis of decoction efficacy, compatibility interpretation, and biomedical applications.Chinese medicine · 2026Review
- Cooperative Ligand-Mediated Transitions in Simple Macromolecules.The journal of physical chemistry. B · 2025Article
- Hydrogels incorporating active compounds from traditional Chinese medicine for diabetic wound healing: mechanistic pathways and bioengineering progress.Frontiers in cell and developmental biology · 2025Review
- Elucidation of Protonation Cooperativity of a STING-Activating Polymer.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Charge Regulation of Poly(acrylic acid) in Solutions of Non-Charged Polymer and Colloids.Polymers · 2023Article
- Cooperative transitions involving hydrophobic polyelectrolytes.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Phase Separation of Aqueous Poly(diisopropylaminoethyl methacrylate) upon Heating.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA.Trends in pharmacological sciences · 2021Review
- Polycarbonate-based ultra-pH sensitive nanoparticles improve therapeutic window.Nature communications · 2020Article
- Modular Fabrication of Intelligent Material-Tissue Interfaces for Bioinspired and Biomimetic Devices.Progress in materials science · 2019Article
- Transistor-like Ultra-pH-Sensitive Polymeric Nanoparticles.Accounts of chemical research · 2019Review
- Enhancing the In Vitro and In Vivo Stabilities of Polymeric Nucleic Acid Delivery Nanosystems.Bioconjugate chemistry · 2019Review
- Recent Development of pH-Responsive Polymers for Cancer Nanomedicine.Molecules (Basel, Switzerland) · 2018Review
- Cooperativity Principles in Self-Assembled Nanomedicine.Chemical reviews · 2018Review
- Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications.Theranostics · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Self-assembly and associated dynamic and reversible non-covalent interactions are the basis of protein biochemistry (e.g., protein folding) and development of sophisticated nanomaterial systems that can respond to and amplify biological signals. In this study, we report a systematic investigation of non-covalent interactions that affect the pH responsive behaviors and resulting supramolecular self-assembly of a series of ultra-pH sensitive (UPS) block copolymers. Increase of hydrophobic and π-π stacking interactions led to the decrease of pKa values. In contrast, enhancement of direct ionic binding between cationic ammonium groups and anionic counter ions gave rise to increased pKa. Moreover, hydration of hydrophobic surfaces and hydrogen bonding interactions may also play a role in the self-assembly process. The key parameters capable of controlling the subtle interplay of different non-covalent bonds in pH-triggered self-assembly of UPS copolymers are likely to offer molecular insights to understand other stimuli-responsive nanosystems. Selective and precise implementation of non-covalent interactions in stimuli-responsive self-assembly processes will provide powerful and versatile tools for the development of dynamic, complex nanostructures with predictable and tunable transitions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.