ArticleFrontiers in immunology2017
Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Mumps virus infection triggers early pro-inflammatory responses and impairs Leydig and Sertoli cell function in an ex vivo human testis model.Human reproduction (Oxford, England) · 2025Article
- Targeting SHP-1 to alleviate testicular inflammation and apoptosis in a Poly(I:C)-induced orchitis model.European journal of medical research · 2025Article
- Testis Is a Sanctuary Site for HIV-1.Advances in experimental medicine and biology · 2025Review
- A Comprehensive Bibliometric Analysis of Orchitis Research from 1980 to 2023.Advances in experimental medicine and biology · 2025Review
- Innate Antiviral Defense of the Male Reproductive System.Advances in experimental medicine and biology · 2025Review
- Testicular immunity.Molecular aspects of medicine · 2024Review
- A multi-omics analysis of viral nucleic acid poly(I:C) responses to mammalian testicular stimulation.Stress biology · 2024Article
- Adeno-associated-virus-mediated delivery of CRISPR-CasRx induces efficient RNA knockdown in the mouse testis.Theranostics · 2024Article
- Viral Infections and Male Infertility: A Comprehensive Review of the Role of Oxidative Stress.Frontiers in reproductive health · 2022Review
- Viral tropism for the testis and sexual transmission.Frontiers in immunology · 2022Review
- Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The impact of SARS-CoV-2 and COVID-19 on male reproduction and men's health.Fertility and sterility · 2021Review
- Mumps Orchitis: Clinical Aspects and Mechanisms.Frontiers in immunology · 2021Review
- Immunologic Environment of the Testis.Advances in experimental medicine and biology · 2021Article
- Characterization of an Antiviral Component in Human Seminal Plasma.Frontiers in immunology · 2021Article
- Intruder (DD38E), a recently evolved sibling family of DD34E/Tc1 transposons in animals.Mobile DNA · 2020Article
- Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells.Frontiers in microbiology · 2020Article
- Mumps virus infection disrupts blood-testis barrier through the induction of TNF-α in Sertoli cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Male germ cells support long-term propagation of Zika virus.Nature communications · 2018Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mumps virus (MuV) infection has high tropism to the testis and usually leads to orchitis, an etiological factor in male infertility. However, MuV replication in testicular cells and the cellular antiviral responses against MuV are not fully understood. The present study showed that MuV infected the majority of testicular cells, including Leydig cells (LC), testicular macrophages, Sertoli cells (SC), and male germ cells (GC). MuV was replicated at relatively high efficiencies in SC compared with LC and testicular macrophages. In contrast, MuV did not replicate in male GC. Notably, testicular cells exhibited different innate antiviral responses against MuV replication. We showed that interferon β (IFN-β) inhibited MuV replication in LC, macrophages, and SC, which were associated with the upregulation of major antiviral proteins. We provided primary evidence that autophagy plays a role in blocking MuV replication in male GC. Autophagy was also involved in limiting MuV replication in testicular macrophages but not in Leydig and SC. These findings indicate the involvement of the innate defense against MuV replication in testicular cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.