Evidence map›Paper›PMID 28239381›Full record

ArticleFrontiers in immunology2017

Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8

Nadine Honke, Namir Shaabani, John R Teijaro, Urs Christen, Cornelia Hardt, Judith Bezgovsek, Philipp A Lang, Karl S Lang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nadine HonkeMedical Faculty, Institute of Immunology, University of Duisburg-Essen, Essen, Germany; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.
Namir ShaabaniMedical Faculty, Institute of Immunology, University of Duisburg-Essen, Essen, Germany; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA.
John R TeijaroDepartment of Immunology and Microbial Science, The Scripps Research Institute , La Jolla, CA , USA.
Urs ChristenPharmazentrum Frankfurt, Goethe University Hospital Frankfurt , Frankfurt am Main , Germany.
Cornelia HardtMedical Faculty, Institute of Immunology, University of Duisburg-Essen , Essen , Germany.
Judith BezgovsekMedical Faculty, Institute of Immunology, University of Duisburg-Essen , Essen , Germany.
Philipp A LangClinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany; Medical Faculty, Department of Molecular Medicine II, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Karl S LangMedical Faculty, Institute of Immunology, University of Duisburg-Essen, Essen, Germany; Clinic of Gastroenterology, Hepatology and Infectious Diseases, Heinrich-Heine-University, Düsseldorf, Germany.
University of Duisburg-Essen · DEHeinrich Heine University Düsseldorf · DEScripps Research Institute · USGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral tolerance is an important mechanism by which the immune system can guarantee a second line of defense against autoreactive T and B cells. One autoimmune disease that is related to a break of peripheral tolerance is diabetes mellitus type 1. Using the RIP-GP mouse model, we analyzed the role of the spleen and lymph nodes (LNs) in priming CD8

Indexed as

autoimmune diabetesenforced viral replicationLCMVlymph nodessphingosine-1-phosphate receptor

Identifiers

PMID28239381
PMCPMC5301005
OpenAlexW2587300858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.