ArticleFrontiers in cellular neuroscience2017
Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves.
Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 54 citations in OpenAlex.
- Enhancing peripheral nerve regeneration in aging: the role of Schwann cells, c-Jun, and emerging therapeutic strategies.GeroScience · 2026Review
- A Comparison of the Effects of Vitamin B12 and Folic Acid on Gait Recovery and Myelination After Femoral Nerve Injury in Rats.International journal of molecular sciences · 2026Article
- Near infrared fluorophore specific for annexin A2 identifies peripheral nerve injury in a rodent transection model.Frontiers in cell and developmental biology · 2026Article
- [Construction of a predictive model for postoperative pain relief after microscopic spermatic cord surgery for spermatic cord pain].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Exosomes repairment for sciatic nerve injury: a cell-free therapy.Stem cell research & therapy · 2024Review
- Article
- Type I collagen extracellular matrix facilitates nerve regeneration via the construction of a favourable microenvironment.Burns & trauma · 2024Article
- Transcription Factor BCL11A Regulates Schwann Cell Behavior During Peripheral Nerve Regeneration.Molecular neurobiology · 2023Article
- Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation.Neural regeneration research · 2022Review
- Robust temporal changes of cellular senescence and proliferation after sciatic nerve injury.Neural regeneration research · 2022Article
- Identification of key genes involved in axon regeneration and Wallerian degeneration by weighted gene co-expression network analysis.Neural regeneration research · 2022Article
- Erectile dysfunction resulting from pelvic surgery is associated with changes in cavernosal gene expression indicative of cavernous nerve injury.Andrologia · 2022Article
- Transcription factor SS18L1 regulates the proliferation, migration and differentiation of Schwann cells in peripheral nerve injury.Frontiers in veterinary science · 2022Article
- Expression of Protein Acetylation Regulators During Peripheral Nerve Development, Injury, and Regeneration.Frontiers in molecular neuroscience · 2022Article
- Endocytosis-associated patterns in nerve regeneration after peripheral nerve injury.Journal of orthopaedic translation · 2021Article
- Transcriptome analysis of molecular mechanisms underlying facial nerve injury repair in rats.Neural regeneration research · 2021Article
- Transcriptomic analysis reveals essential microRNAs after peripheral nerve injury.Neural regeneration research · 2021Article
- A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity.Frontiers in molecular biosciences · 2021Review
- Characteristics of cytokines in the sciatic nerve stumps and DRGs after rat sciatic nerve crush injury.Military Medical Research · 2020Article
- Sequencing analysis of matrix metalloproteinase 7-induced genetic changes in Schwann cells.Neural regeneration research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wallerian degeneration occurs immediately following injury to mammal peripheral nerves. To better understand the molecular events occurring during Wallerian degeneration, a rat model of sciatic nerve transection was used to assess differentially expressed genes at 0.5, 1, 6, 12, 24 h, 4 days, 1, 2, 3, and 4 weeks post nerve injury (PNI). Hierarchical clustering, Euclidean distance matrix, and principal component analysis (PCA) collectively suggested three distinct phases within the post-injury period of 4 weeks. Gene ontology (GO) analysis suggested that phase I (0-6 h PNI), phase II (6-24 h PNI), and phase III (4 days to 4 weeks) were associated with acute response to injury, preformation of Wallerian degeneration, and complete execution of Wallerian degeneration, respectively. Critical signaling pathways and transcriptional factor networks responsible for the regulation of Wallerian degeneration were further identified and integrated using Kyoto Enrichment of Genes and Genomes (KEGG) pathway analysis and Ingenuity Pathway Analysis (IPA), respectively. Our results may help to elucidate some molecular mechanisms of gene regulation associated with Wallerian degeneration that occurs after traumatic injury to peripheral nerve axons in mammals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.