ArticleFrontiers in cellular neuroscience2017
Differential Neural Responses Underlying the Inhibition of the Startle Response by Pre-Pulses or Gaps in Mice.
Article in Frontiers in cellular neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Human promoter-driven AAV tools enable precision gene therapy targeting cochlear hair cells.Cell reports. Medicine · 2026Article
- Altered Auditory Maturation in Fragile X Syndrome and Its Involvement in Audiogenic Seizure Susceptibility.Autism research : official journal of the International Society for Autism Research · 2026Article
- Inhibition of Cortical Evoked Responses to Sound Pulses by Preceding Silent Gaps.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- A molecular mechanism mediating clozapine-enhanced sensorimotor gating.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Postnatal environment affects auditory development and sensorimotor gating in a rat model for autism spectrum disorder.Frontiers in neuroscience · 2025Article
- Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus.Biomedicines · 2024Article
- From hidden hearing loss to supranormal auditory processing by neurotrophin 3-mediated modulation of inner hair cell synapse density.PLoS biology · 2024Article
- Inhibitory effects of prepulse stimuli on the electrophysiological responses to startle stimuli in the deep layers of the superior colliculus.Frontiers in neuroscience · 2024Article
- Identifying tinnitus in mice by tracking the motion of body markers in response to an acoustic startle.Frontiers in neuroscience · 2024Article
- The Auditory Brainstem Response (ABR) Test, Supplementary to Behavioral Tests for Evaluation of the Salicylate-Induced Tinnitus.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Gap pre-pulse inhibition of the cortical auditory evoked potentials as a possible objective tinnitus assessment tool.Iranian journal of child neurology · 2023Article
- Diverse functions of the auditory cortico-collicular pathway.Hearing research · 2022Review
- Circadian Sensitivity of Noise Trauma-Induced Hearing Loss and Tinnitus in Mongolian Gerbils.Frontiers in neuroscience · 2022Article
- A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes.Nature communications · 2021Article
- Acoustically Enriched Environment during the Critical Period of Postnatal Development Positively Modulates Gap Detection and Frequency Discrimination Abilities in Adult Rats.Neural plasticity · 2021Article
- Salicylate-Induced Changes in Hearing Thresholds in Mongolian Gerbils Are Correlated With Tinnitus Frequency but Not With Tinnitus Strength.Frontiers in behavioral neuroscience · 2021Article
- A role of oligodendrocytes in information processing.Nature communications · 2020Article
- Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms.Brain sciences · 2020Review
- Increasing endogenous activity of NMDARs on GABAergic neurons increases inhibition, alters sensory processing and prevents noise-induced tinnitus.Scientific reports · 2020Article
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3 authors.
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Abstract
Gap pre-pulse inhibition of the acoustic startle (GPIAS) is a behavioral paradigm used for inferring the presence of tinnitus in animal models as well as humans. In contrast to pre-pulse inhibition (PPI), the neural circuitry controlling GPIAS is poorly understood. To increase our knowledge on GPIAS, a comparative study with PPI was performed in mice combining these behavioral tests and c-Fos activity mapping in brain areas involved in the inhibition of the acoustic startle reflex (ASR). Both pre-pulses and gaps efficiently inhibited the ASR and abolished the induction of c-Fos in the pontine reticular nucleus. Differential c-Fos activation was found between PPI and GPIAS in the forebrain whereby PPI activated the lateral globus pallidus and GPIAS activated the primary auditory cortex. Thus, different neural maps are regulating the inhibition of the startle response by pre-pulses or gaps. To further investigate this differential response to PPI and GPIAS, we pharmacologically disrupted PPI and GPIAS with D-amphetamine or Dizocilpine (MK-801) to target dopamine efflux and to block NMDA receptors, respectively. Both D-amp and MK-801 efficiently decreased PPI and GPIAS. We administered Baclofen, an agonist GABA
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