ArticleJournal of the Royal Statistical Society. Series C, Applied statistics2017
Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study.
Article in Journal of the Royal Statistical Society. Series C, Applied statistics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Extrapolation before imputation reduces bias when imputing censored covariates.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2025Article
- Making Sense of Censored Covariates: Statistical Methods for Studies of Huntington's Disease.Annual review of statistics and its application · 2024Article
- Understanding the implications of a complete case analysis for regression models with a right-censored covariate.The American statistician · 2024Article
- Semiparametric analysis of a generalized linear model with multiple covariates subject to detection limits.Statistics in medicine · 2022Article
- Correcting conditional mean imputation for censored covariates and improving usability.Biometrical journal. Biometrische Zeitschrift · 2022Article
- Mechanism-aware imputation: a two-step approach in handling missing values in metabolomics.BMC bioinformatics · 2022Article
- Measuring association among censored antibody titer data.Statistics in medicine · 2021Article
- Cox regression model with randomly censored covariates.Biometrical journal. Biometrische Zeitschrift · 2019Article
- Improved conditional imputation for linear regression with a randomly censored predictor.Statistical methods in medical research · 2019Article
- Threshold regression to accommodate a censored covariate.Biometrics · 2018Article
- Cox model with interval-censored covariate in cohort studies.Biometrical journal. Biometrische Zeitschrift · 2018Article
- Cadmium and Alzheimer's disease mortality in U.S. adults: Updated evidence with a urinary biomarker and extended follow-up time.Environmental research · 2017Article
- Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring.Neurobiology of aging · 2016Article
- Multiple Imputation of a Randomly Censored Covariate Improves Logistic Regression Analysis.Journal of applied statistics · 2016Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The association between maternal age of onset of dementia and amyloid deposition (measured by in vivo positron emission tomography (PET) imaging) in cognitively normal older offspring is of interest. In a regression model for amyloid, special methods are required due to the random right censoring of the covariate of maternal age of onset of dementia. Prior literature has proposed methods to address the problem of censoring due to assay limit of detection, but not random censoring. We propose imputation methods and a survival regression method that do not require parametric assumptions about the distribution of the censored covariate. Existing imputation methods address missing covariates, but not right censored covariates. In simulation studies, we compare these methods to the simple, but inefficient complete case analysis, and to thresholding approaches. We apply the methods to the Alzheimer's study.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.