Evidence map›Paper›PMID 28239189›Full record

ArticleCroatica chemica acta. Arhiv za kemiju2016

Pyrrolysyl-tRNA synthetase, an aminoacyl-tRNA synthetase for genetic code expansion.

Ana Crnković, Tateki Suzuki, Dieter Söll, Noah M Reynolds

Open access · diamondAbstract read
In one paragraph

Article in Croatica chemica acta. Arhiv za kemiju, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Expanding the Genetic Code ofACS chemical biology · 2024
    Article
  6. Article
  7. Update of the Pyrrolysyl-tRNA Synthetase/tRNAJournal of bacteriology · 2023
    Review
  8. Chemically Acylated tRNAs are Functional in Zebrafish Embryos.Journal of the American Chemical Society · 2023
    Article
  9. Article
  10. Ancestral archaea expanded the genetic code with pyrrolysine.The Journal of biological chemistry · 2022
    Article
  11. Review
  12. Directed Evolution ofFrontiers in molecular biosciences · 2022
    Article
  13. Article
  14. Article
  15. Understanding the Genetic Code.Journal of bacteriology · 2019
    Review
  16. Article
  17. Review
  18. tRNARNA biology · 2018
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ana CrnkovićDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA.
Tateki SuzukiDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA.
Dieter SöllDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA.; Department of Chemistry, Yale University, New Haven, CT 06520-8114, USA.
Noah M ReynoldsDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520-8114, USA.
Yale University · US

Funding

TRANSFER RNAR01GM022854 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER · 1985 to 2016
$21.3M
TRANSFER RNAR37GM022854 · NIGMS · YALE UNIVERSITY · PI SOLL, DIETER G · 1991 to 2000
$786k
NIGMS NIH HHS R01 GM022854NIGMS NIH HHS R37 GM022854
6 · The paper itself

Abstract

Genetic code expansion (GCE) has become a central topic of synthetic biology. GCE relies on engineered aminoacyl-tRNA synthetases (aaRSs) and a cognate tRNA species to allow codon reassignment by co-translational insertion of non-canonical amino acids (ncAAs) into proteins. Introduction of such amino acids increases the chemical diversity of recombinant proteins endowing them with novel properties. Such proteins serve in sophisticated biochemical and biophysical studies both

Indexed as

genetic code expansionnon-canonical amino acidpyrrolysyl-tRNA synthetasestop codon suppressionsynthetic biologytRNAPyl

Identifiers

PMID28239189
PMCPMC5321558
OpenAlexW2443220578

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.