Association between DNA methylation at SOCS3 gene and body mass index might be due to familial confounding.

S Li, E M Wong, M C Southey, J L Hopper

Abstract readLetterComment

In one paragraph

Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

0.8field-weighted citation impact, top 29% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters.BMC medicine · 2026
Article
Climate-related disasters and biological aging based on DNA methylation: a twin and family study in Australian women.International journal of epidemiology · 2025
Article
Surrounding Greenness and Biological Aging Based on DNA Methylation: A Twin and Family Study in Australia.Environmental health perspectives · 2021
Article
Inference about causation from examination of familial confounding (ICE FALCON): a model for assessing causation analogous to Mendelian randomization.International journal of epidemiology · 2020
Article
Inference about causation between body mass index and DNA methylation in blood from a twin family study.International journal of obesity (2005) · 2019
Article
Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study.Clinical epigenetics · 2018
Article

4 · The record

Corrections and comments

Comment on
An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort.2017

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

S LiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.

E M WongGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

M C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.

J L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.

University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA MethylationSuppressor of Cytokine Signaling ProteinsBody Mass IndexCohort StudiesSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling 3 ProteinSuppressor of Cytokine Signaling Proteins

Identifiers

PMID28239163

DOI10.1038/ijo.2017.56

OpenAlexW2592687613

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.